Results 61 to 70 of about 1,977,172 (267)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
MathematicsThe estimation of correlation matrices in high-dimensional data streams presents a fundamental conflict between computational efficiency and statistical robustness.
Sooyoung Jang, Changbeom Choi
doaj +1 more source
The Breakdown Point — Examples and Counterexamples
Revstat Statistical Journal, 2007 The breakdown point plays an important though at times controversial role in statistics. In situations in which it has proved most successful there is a group of transformations which act on the sample space and which give rise to an equivariance ...
P.L. Davies , U. Gather
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Applications of Robust Statistics in Autonomous Driving
IEEE AccessAutonomous vehicles have to interact with their environment with the goal to fulfill their tasks while respecting all desired constraints such as not causing dangerous situations, driving comfortable maneuvers, enabling a smooth traffic flow, or avoiding
Tino Werner
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Improving standards in brain-behaviour correlation analyses
Frontiers in Human Neuroscience, 2012 Associations between two variables, for instance between brain and behavioural measurements, are often studied using Pearson correlation. However, Pearson correlation is not robust: outliers can introduce false correlations or mask existing ones.
Guillaume A Rousselet, Cyril R Pernet
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
How to Address Non-normality: A Taxonomy of Approaches, Reviewed, and Illustrated
Frontiers in Psychology, 2018 The linear model often serves as a starting point for applying statistics in psychology. Often, formal training beyond the linear model is limited, creating a potential pedagogical gap because of the pervasiveness of data non-normality.
Jolynn Pek +3 more
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Classical singularities and Semi-Poisson statistics in quantum chaos and disordered systems
, 2005 We investigate a 1D disordered Hamiltonian with a non analytical step-like dispersion relation whose level statistics is exactly described by Semi-Poisson statistics(SP).
Antonio M. García-García +2 more
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
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