Results 81 to 90 of about 2,082,460 (297)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Robustness of Anytime Bandit Policies [PDF]
, 2011 This paper studies the deviations of the regret in a stochastic multi-armed bandit problem. When the total number of plays n is known beforehand by the agent, Audibert et al.
Audibert, Jean-Yves, Salomon, Antoine
core +3 more sources
Knockouts, Robustness and Cell Cycles
, 2010 The response to a knockout of a node is a characteristic feature of a networked dynamical system. Knockout resilience in the dynamics of the remaining nodes is a sign of robustness.
A. Wagner +7 more
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Ecology and Society, 2014 The insights in Governing the Commons have provided foundational ideas for commons research in the past 23 years. However, the cases that Elinor Ostrom analyzed have been exposed to new social, economic, and ecological disturbances.
Allain J. . Barnett, John M. Anderies
doaj +1 more source
Adversarial Robustness: Softmax versus Openmax
, 2017 Deep neural networks (DNNs) provide state-of-the-art results on various tasks and are widely used in real world applications. However, it was discovered that machine learning models, including the best performing DNNs, suffer from a fundamental problem ...
Boult, Terrance E. +2 more
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Developmental Evolution: Getting Robust About Robustness [PDF]
Current Biology, 2002 In the context of development, a process is robust if it can proceed normally despite the enormous capacity for perturbation inherent in all biological systems. A new mode of theoretical modeling of genetic networks holds great promise for increasing our understanding of both the quantitative mechanisms of robustness and its evolutionary impact.
openaire +3 more sources
Performance Assessment of a Model-based DC Motor Scheme
Applications of Modelling and Simulation, 2019 The separately-excited DC motor is a high-performance variable speed drive with industrial applications such as in robotics, actuation, control and guided manipulation due to its precision, simplicity, continuous control feature and wide speed range ...
Ihechiluru S. Okoro, Clinton O. Enwerem
doaj