Results 91 to 100 of about 548,676 (308)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Violations of robustness trade‐offs

Molecular Systems Biology, 2010
Biological robustness is a principle that may shed light on system‐level characteristics of biological systems. One intriguing aspect of the concept of biological robustness is the possible existence of intrinsic trade‐offs among robustness, fragility ...
Hiroaki Kitano
doaj   +1 more source

Robust and simple database evolution

Information Systems Frontiers, 2017
This is the artifact for the paper titled "POKER: Permutation-based SIMD Execution of Intensive Tree Search by Path Encoding" accepted at CGO 2018. This artifact helps reproduce the results presented in Figures 7 - 9 and Tables 2 - 3 in Section 4. For more information on how to use it, please refer to our paper and the README.txt file in this package ...
Herrmann, Kai, Voigt, Hannes, Rausch, Jonas, Behrend, Andreas, Lehner, Wolfgang   +4 more
openaire   +3 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Parasites lead to evolution of robustness against gene loss in host signaling networks

Molecular Systems Biology, 2008
Many biological networks can maintain their function against single gene loss. However, the evolutionary mechanisms responsible for such robustness remain unclear.
Marcel Salathé, Orkun S Soyer
doaj   +1 more source

Quantum localization bounds Trotter errors in digital quantum simulation

, 2019
A fundamental challenge in digital quantum simulation (DQS) is the control of an inherent error, which appears when discretizing the time evolution of a quantum many-body system as a sequence of quantum gates, called Trotterization.
Hauke, P., Heyl, M., Zoller, P.
core   +1 more source

On Robust Evolution of Digital Hardware [PDF]

, 2008
In this paper we investigate whether multi-objective evolution of digital hardware components has advantages over single-objective evolution in terms of convergence and robustness. To that end, we experimentally compare a standard genetic algorithm to several multi-objective optimizers on a set of test problems.
Tobias Knieper, Bertrand Defo, Paul Kaufmann, Marco Platzner   +3 more
openaire   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

A direct experimental test of Ohno’s hypothesis

eLife
Gene duplication drives evolution by providing raw material for proteins with novel functions. An influential hypothesis by Ohno (1970) posits that gene duplication helps genes tolerate new mutations and thus facilitates the evolution of new phenotypes ...
Ljiljana Mihajlovic, Bharat Ravi Iyengar, Florian Baier, Içvara Barbier, Justyna Iwaszkiewicz, Vincent Zoete, Andreas Wagner, Yolanda Schaerli   +7 more
doaj   +1 more source