Results 91 to 100 of about 562,963 (309)
Electronic Journal of Qualitative Theory of Differential Equations, 2011 In this paper, we study periodic boundary value problems for a class of linear fractional evolution equations involving the Caputo fractional derivative.
JinRong Wang, Yong Zhou, Michal Fečkan
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Co-evolution, Determinism and Robustness
, 1999 Robustness has long been recognised as a critical issue for coevolutionary learning. It has been achieved in a number of cases, though usually in domains which involve some form of non-determinism. We examine a deterministic domain - a pseudo real-time two-player game called Tron - and evolve a neural network player using a simple hill-climbing ...
A.D. Blair, Elizabeth Sklar, P. Funes
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Robustness of Phylogenetic Inference Based on Minimum Evolution
Bulletin of Mathematical Biology, 2010 Minimum evolution is the guiding principle of an important class of distance-based phylogeny reconstruction methods, including neighbor-joining (NJ), which is the most cited tree inference algorithm to date. The minimum evolution principle involves searching for the tree with minimum length, where the length is estimated using various least-squares ...
Pardi, Fabio +2 more
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A direct experimental test of Ohno’s hypothesis
eLifeGene duplication drives evolution by providing raw material for proteins with novel functions. An influential hypothesis by Ohno (1970) posits that gene duplication helps genes tolerate new mutations and thus facilitates the evolution of new phenotypes ...
Ljiljana Mihajlovic +7 more
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Parasites lead to evolution of robustness against gene loss in host signaling networks
Molecular Systems Biology, 2008 Many biological networks can maintain their function against single gene loss. However, the evolutionary mechanisms responsible for such robustness remain unclear.
Marcel Salathé, Orkun S Soyer
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Quantum localization bounds Trotter errors in digital quantum simulation
, 2019 A fundamental challenge in digital quantum simulation (DQS) is the control of an inherent error, which appears when discretizing the time evolution of a quantum many-body system as a sequence of quantum gates, called Trotterization.
Hauke, P., Heyl, M., Zoller, P.
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Impact of translational error‐induced and error‐free misfolding on the rate of protein evolution
Molecular Systems Biology, 2010 What determines the rate of protein evolution is a fundamental question in biology. Recent genomic studies revealed a surprisingly strong anticorrelation between the expression level of a protein and its rate of sequence evolution.
Jian‐Rong Yang +2 more
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