Results 41 to 50 of about 99,185 (278)
Environmental noise, genetic diversity and the evolution of evolvability and robustness in model gene networks. [PDF]
PLoS ONE, 2012 The ability of organisms to adapt and persist in the face of environmental change is accepted as a fundamental feature of natural systems. More contentious is whether the capacity of organisms to adapt (or "evolvability") can itself evolve and the ...
Christopher F Steiner
doaj +1 more source
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Robustness evolution of collaborative innovation network in China’s smart grid industry
Sustainable FuturesClarifying the evolution trend of network robustness is of great significance to how to protect and maintain the structure and performance of collaborative innovation networks of China's smart grid industry.
Yuan Tao
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Evolution of robustness to noise and mutation in gene expression dynamics.
PLoS ONE, 2007 Phenotype of biological systems needs to be robust against mutation in order to sustain themselves between generations. On the other hand, phenotype of an individual also needs to be robust against fluctuations of both internal and external origins that ...
Kunihiko Kaneko
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Non-Darwinian Molecular Biology
Frontiers in Genetics, 2022 With the discovery of the double helical structure of DNA, a shift occurred in how biologists investigated questions surrounding cellular processes, such as protein synthesis. Instead of viewing biological activity through the lens of chemical reactions,
Alexander F. Palazzo, Nevraj S. Kejiou
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FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
The robustness of a signaling complex to domain rearrangements facilitates network evolution. [PDF]
PLoS Biology, 2014 The rearrangement of protein domains is known to have key roles in the evolution of signaling networks and, consequently, is a major tool used to synthetically rewire networks.
Paloma M Sato +3 more
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From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
The Stochastic Evolutionary Game for a Population of Biological Networks under Natural Selection
Evolutionary Bioinformatics, 2014 In this study, a population of evolutionary biological networks is described by a stochastic dynamic system with intrinsic random parameter fluctuations due to genetic variations and external disturbances caused by environmental changes in the ...
Bor-Sen Chen, Shih-Ju Ho
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Mechanisms of Mutational Robustness in Transcriptional Regulation
Frontiers in Genetics, 2015 Robustness is the invariance of a phenotype in the face of environmental or genetic change. The phenotypes produced by transcriptional regulatory circuits are gene expression patterns that are to some extent robust to mutations.
Joshua L. Payne +4 more
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