Evolving robust gene regulatory networks. [PDF]
PLoS ONE, 2015 Design and implementation of robust network modules is essential for construction of complex biological systems through hierarchical assembly of 'parts' and 'devices'.
Nasimul Noman +3 more
doaj +1 more source
Scale-free networks are not robust under neutral evolution
, 2001 Recently it has been shown that a large variety of different networks have power-law (scale-free) distributions of connectivities. We investigate the robustness of such a distribution in discrete threshold networks under neutral evolution.
Bollobás B. +7 more
core +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Robustness of the long-term nonlinear evolution of global sea surface temperature trend
Geoscience Letters, 2022 The multi-scale variability of global sea surface temperature (GSST), which is often dominated by secular trends, significantly impacts global and regional climate change. Previous studies were mainly carried out under linear assumptions.
Zhenhao Xu +5 more
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Epigenetics decouples mutational from environmental robustness. Did it also facilitate multicellularity? [PDF]
PLoS Computational Biology, 2014 The evolution of ever increasing complex life forms has required innovations at the molecular level in order to overcome existing barriers. For example, evolving processes for cell differentiation, such as epigenetic mechanisms, facilitated the ...
Saurabh Gombar +2 more
doaj +1 more source
Robustness Evolution: Building robust critical networks with the 5G System [PDF]
, 2021 Jari Vikberg +4 more
openalex +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Evolution with Drifting Targets [PDF]
, 2010 We consider the question of the stability of evolutionary algorithms to gradual changes, or drift, in the target concept. We define an algorithm to be resistant to drift if, for some inverse polynomial drift rate in the target function, it converges to ...
Kanade, Varun +2 more
core +4 more sources
Robust stationary entanglement of two coupled qubits in independent environments
, 2010 The dissipative dynamics of two interacting qubits coupled to independent reservoirs at nonzero temperatures is investigated, paying special attention to the entanglement evolution.
A. Imamoglu +45 more
core +1 more source