Results 131 to 140 of about 2,525,063 (363)

MUTE‐Seq: An Ultrasensitive Method for Detecting Low‐Frequency Mutations in cfDNA With Engineered Advanced‐Fidelity FnCas9

open access: yesAdvanced Materials, EarlyView.
An advanced‐fidelity CRISPR nuclease, FnCas9‐AF2, is rationally engineered to discriminate single‐base mismatches with unprecedented level precision. Integrated into the MUTE‐Seq workflow, FnCas9‐AF2 depletes wild‐type cell‐free DNA, thereby exposing rare tumor‐derived mutant DNA (a molecular “needle in a haystack”).
Sunghyeok Ye   +20 more
wiley   +1 more source

Model Assessment with ROC Curves [PDF]

open access: yes, 2009
Classification models and in particular binary classification models are ubiquitous in many branches of science and business. Consider, for example, classification models in bioinformatics that classify catalytic protein structures as being in an active or inactive conformation.
openaire   +1 more source

On the shape of energy-detection ROC curves [PDF]

open access: yesPerception & Psychophysics, 1990
A numerical study shows that energy-detection ROC curves based on chi-squared distributions may be accurately represented by binormal receiver operating characteristic (ROC) curves. This allows the detector accuracy and the ROC shape (asymmetry) to be expressed simply in terms of the distribution parameters.
openaire   +3 more sources

Learning Crystallographic Disorder: Bridging Prediction and Experiment in Materials Discovery

open access: yesAdvanced Materials, EarlyView.
Machine learning based computational materials discovery workflows have recently proposed thousands of potentially stable crystalline materials. However, the experimental realization of these predictions is often challenging because the models assume perfectly ordered structures.
Konstantin S. Jakob   +3 more
wiley   +1 more source

ODC and ROC Curves, Comparison Curves and Stochastic Dominance

open access: yesInternational Statistical Review
SummaryWe discuss two novel approaches to inter‐distributional comparisons in the classical two‐sample problem. Our starting point is properly standardised and combined, very popular in several areas of statistics and data analysis, ordinal dominance and receiver characteristic curves, denoted by ODC and ROC, respectively.
Teresa Ledwina, Adam Zagdański
openaire   +2 more sources

AI‐Enhanced Gait Analysis Insole with Self‐Powered Triboelectric Sensors for Flatfoot Condition Detection

open access: yesAdvanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
The given research presents an innovative insole‐based device employing self‐powered triboelectric nanogenerators (TENG) for flatfoot detection. By integrating TENG tactile sensors within an insole, the device converts mechanical energy from foot movements to electrical signals analyzed via machine learning, achieving an 82% accuracy rate in flatfoot ...
Moldir Issabek   +7 more
wiley   +1 more source

Understanding and Circumventing Failure Mechanisms in Chalcogenide Optical Phase Change Material Ge2Sb2Se4Te

open access: yesAdvanced Optical Materials, Volume 13, Issue 8, March 13, 2025.
Chalcogenide optical PCMs have gathered interest for their potential in compact, non‐volatile optics and photonics. Free‐space PCM metasurfaces require new considerations from phase change memory that need to be addressed for reliable scale‐up. Several failure mechanisms pertaining to free‐space PCM devices and layout methods are isolated to prevent ...
Cosmin Constantin Popescu   +19 more
wiley   +1 more source

Advancing Clinical Medicine with Raman Spectroscopy: Current Trends and Future Perspectives

open access: yesAdvanced Photonics Research, EarlyView.
Raman spectroscopy and microscopy may become excellent tools in clinical medicine, including hematology, oncology, infectious diseases, neurology, gastroenterology, reproductive medicine, rheumatology, and cardiovascular research. However, many challenges such as signal interference, standardization issues, and limited clinical application need to be ...
Jiří Bufka   +5 more
wiley   +1 more source

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