Results 71 to 80 of about 142,974 (226)

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

Numerical Investigation of Rock Breaking Mechanisms by High Pressure Water Jet

Procedia Engineering, 2015
AbstractMany factors and complexities are involved in breaking rock with a high-pressure water jet, which has made it difficult to explain the rock breaking internal mechanisms. This in turn has constrained the applications and development of water jet technology.
Chen, Hailong, Li, Zhaomin, Gao, Zhihan, Sun, Yuanyuan   +3 more
openaire   +1 more source

Research on the Hard-Rock Breaking Mechanism of Hydraulic Drilling Impact Tunneling [PDF]

Mathematical Problems in Engineering, 2015
In order to realize the rapid hard-rock tunneling in a safe, highly effective, and economic manner, the hydraulic drilling impact hard-rock tunneling (HDIHT) technology and method were introduced based on the theories of rock mechanics and hydraulic impact. The key parameters, including drilling radius and impact distance, were researched to reveal the
Risheng Long, Shaoni Sun, Zisheng Lian
openaire   +1 more source

Solitonic State in Microscopic Dynamic Failures

, 2018
Onset of permanent deformation in crystalline materials under a sharp indenter tip is accompanied by nucleation and propagation of defects. By measuring the spatio-temporal strain field nearthe indenter tip during indentation tests, we demonstrate that ...
Ghaffari, H. O., Griffith, W. A., Pec, M.   +2 more
core   +2 more sources

Mesoporous Carbon Thin Films with Large Mesopores as Model Material for Electrochemical Applications

Advanced Functional Materials, EarlyView.
Mesoporous carbon thin films possessing 70 nm mesopores are prepared on titanium substrates by soft templating of resol resins with a self‐synthesized poly(ethylene oxide)‐block‐poly(hexyl acrylate) block copolymer. A strategy to avoid corrosion of the metal substrate is presented, and the films are extensively characterized in terms of morphology ...
Lysander Q. Wagner, Joshua Schober, Pascal Dippell, Chantal Glatthaar, Smail Mekhilef, David Schäfer, Hannes Hergert, Marcus Rohnke, Matthias T. Elm, Bernd M. Smarsly   +9 more
wiley   +1 more source

Mechanism and influencing factors of rock breaking and pore-forming by water jet in deep coal seam based on the MPM

Meitan xuebao
China has a wealth of abundant coalbed methane (CBM) resources at great depths. However, the low permeability of these deep coal seams coupled with the challenges posed by high-stress pressure environments, hampers efficient gas extraction.
Lei ZHOU, Yan PU, Yu PENG, Binwei XIA, Liulin FANG   +4 more
doaj   +1 more source

A Biologically‐Architected Wear and Damage‐Resistant Nanoparticle Coating From the Radular Teeth of Cryptochiton stelleri

Advanced Functional Materials, EarlyView.
The ultrahard teeth of mollusks that feed on rocky substrates contain a wear‐resistant coating on their surfaces consisting of densely packed mesocrystalline magnetic nanoparticles within an organic matrix. These coatings display significant hardness and toughness through their highly controlled mesocrystalline architectures.
Taifeng Wang, Yu Chen, Ezra Sarmiento, Taige Hao, Atsushi Arakaki, Michiko Nemoto, Pablo Zavattieri, David Kisailus   +7 more
wiley   +1 more source

Plasma-Assisted TBM Cutting Mechanism for Rock Breaking

In the process of tunnel excavation, rocks with great hardness and abrasion are often encountered, which leads to low rock breaking efficiency and serious tool wear. In order to solve this problem, a new TBM cutting mechanism is proposed in this paper. The cutter head is equipped with a plasma torch and a shield cutter.
Wei, Hongxin, Gao, Kuidong, Jiang, Acan, Chen, Hong   +3 more
openaire   +1 more source

Heteroatom‐Engineering Promoted Co9S8 Bi‐functional Electrocatalyst for Hydrazine‐Assisted Hydrogen Production at Industrial Current Density

Advanced Functional Materials, EarlyView.
Fe and P co‐doped Co9S8 nanocorals (Fe, P‐Co9S8) are successfully synthesized by a heteroatom engineering strategy, which exhibit outstanding bifunctional electrocatalytic performance for both the hydrogen evolution reaction (HER) and hydrazine oxidation reaction (HzOR).
Yuying Meng, Chunyan Xiang, Wenbiao Zhang, Dahai Zeng, Bing Du, Bao Zhong, Yue Jiang, Damien Voiry, Qingsheng Gao   +8 more
wiley   +1 more source

The chemical bond as an emergent phenomenon

, 2017
We first argue that the covalent bond and the various closed-shell interactions can be thought of as symmetry broken versions of one and the same interaction, viz., the multi-center bond.
Golden, Jon C., Ho, Vinh, Lubchenko, Vassiliy   +2 more
core   +1 more source