Results 31 to 40 of about 1,015,670 (363)

Process of quantitative evaluation of validity of rock cutting model [PDF]

open access: yesActa Montanistica Slovaca, 2012
Most of complex technical systems, including the rock cutting process, are very difficult to describe mathematically due to limitedhuman recognition abilities depending on achieved state in natural sciences and technology.
Jozef Futó   +3 more
doaj  

A stepwise emergence of evolution in the RNA world

open access: yesFEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

open access: yesFEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää   +2 more
wiley   +1 more source

Rock's pill that rocked the world

open access: yesSouth African Medical Journal, 2010
I was a rookie doctor on the goldmines in the early 1960s. Part of my duties was to look after the families in the villages of the Anglo American mines at Welkom in the Free State. Their invariably large numbers of children prompted me to enquire whether they wished to have assistance in family planning.
openaire   +4 more sources

A TREATISE ON ROCKS, ROCK-WEATHERING AND SOILS. [PDF]

open access: yesJournal of the American Chemical Society, 1905
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openaire   +2 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

Porto Velho e o Rock: historiografia das canções entre os anos 2000 a 2010

open access: yesDas Amazônias
This paper focuses on the analysis of lyrics written by rock bands in Porto Velho, Rondônia, between 2000 and 2010. The central problem discussed in this work is the fact that Porto Velho has not achieved visibility as a city that produces songs with ...
Patrícia Sautiro Fernandes
doaj   +1 more source

El grito de la música, un golpe de emancipación

open access: yesComhumanitas, 2019
Esta exposición transcurre en los «márgenes», en el pensamiento y en la penumbra de un acontecimiento. Aquella dictadura militar (1976-1983) que envolvió a la sociedad argentina, arrebatando los derechos y la justicia de cada uno de los ciudadanos.
Xavier Karolys
doaj   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

open access: yesFEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

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