Results 41 to 50 of about 257,184 (268)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Revista Facultad de Ingeniería, 2019 Pillar replacement in mining works is a technique of using the pillars that are part of the support structures having a high degree of mineralization, which attracts economic interest.
Claudia Yasmin Montaño-Chinchilla +3 more
doaj +1 more source
Albuquerque, 2020 Resenha do livro Rock cá, rock lá: a produção roqueira no Brasil e em Portugal na imprensa – 1970/1985.
Edvaldo Correa Sotana
doaj +1 more source
Rock's pill that rocked the world
South African Medical Journal, 2010 I was a rookie doctor on the goldmines in the early 1960s. Part of my duties was to look after the families in the villages of the Anglo American mines at Welkom in the Free State. Their invariably large numbers of children prompted me to enquire whether they wished to have assistance in family planning.
openaire +3 more sources
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Time-based Signal Processing and 'Shape' in Alternative Rock Recordings
IASPM Journal, 2016 This article considers the impact of time-based signal processors on the ‘shape’ of alternative rock recordings. The concept of musical ‘shape’ is considered here as both textural and gestural.
Samantha Bennett
doaj +1 more source
Rock the Rock of Atherosclerosis [PDF]
Journal of Vascular Medicine & Surgery, 2013 The Rho-Associated Coiled-Coil Containing Protein Kinase (ROCK1 and ROCK2) were one of the downstream effectors of the small GTPase Rho. The Rho/ROCK pathway plays an important role in mediating multiple cellular processes, including endothelial dysfunction, the proliferation and migration of smooth muscle cells, foam cell formation, and arterial ...
openaire +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi +19 more
wiley +1 more source