Results 81 to 90 of about 143,227 (288)

Hydro and geomechanical stability assessment of the bund wall bottom slope of the Dniprovsk tailing dump [PDF]

, 2018
Purpose. The objective is to assess the stability of bund wall components of a hydro-technical structure under the conditions of a tailing dump which hydrodynamic mode has been disrupted during operation.
Soroka, Yu, Tishkov, V, Tymoshchuk, V
core   +1 more source

In Situ Characterisation of Hydrogels via Dynamic Interface Printing

Advanced Science, EarlyView.
ABSTRACT Hydrogels have become pivotal materials for tissue engineering, robotics, biomedical devices, and sensing applications due to their diverse material compositions and tunable mechanical properties. While significant effort has focused on developing novel manufacturing approaches such as extrusion bioprinting and light‐based fabrication methods,
Callum Vidler, Michael Halwes, David J. Collins   +2 more
wiley   +1 more source

Rock Cutting and Crack Propagation of Jointed Rock Mass Within Rough Fractures Based on Point-Splitting Process

Applied Sciences
The rock is the direct object of disc cutter rock-breaking engineering. It contains natural joint surface. To investigate the influence of joint-surface roughness on the rock-breaking process. The hob model is created using AutoCAD software.
Guoye Jing, Hao Huang, Peitao Wang, Meifeng Cai   +3 more
doaj   +1 more source

Surface and bulk properties of ballistic deposition models with bond breaking

, 2013
We introduce a new class of growth models, with a surface restructuring mechanism in which impinging particles may dislodge suspended particles, previously aggregated on the same column in the deposit.
Aarão Reis, Aarão Reis, Barabási, Braunstein, Chame, da Silva, Evans, Evans, Farnudi, Forgerini, Horowitz, Horowitz, Horowitz, José Arnaldo Redinz, Juvenil S. Oliveira Filho, Kardar, Katzav, Khanin, Kolakowska, Kolakowska, Lehnen, Mahan, Meakin, Montalenti, Muraca, Pellegrini, Robledo, Romá, Silveira, Sinkovits, Tiago J. Oliveira, Vold, Yu, Yu   +33 more
core   +1 more source

Coevolutionary dynamics of a variant of the cyclic Lotka-Volterra model with three-agent interactions

, 2020
We study a variant of the cyclic Lotka-Volterra model with three-agent interactions. Inspired by a multiplayer variation of the Rock-Paper-Scissors game, the model describes an ideal ecosystem in which cyclic competition among three species develops ...
Ferriani, Stefano, Palombi, Filippo, Toti, Simona   +2 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Lessons from LIMK1 enzymology and their impact on inhibitor design [PDF]

, 2019
LIM domain kinase 1 (LIMK1) is a key regulator of actin dynamics. It is thereby a potential therapeutic target for the prevention of fragile X syndrome and amyotrophic lateral sclerosis.
Beltrami, A, Bullock, Alexander, Canning, P, Chaikuad, A, Chatterjee, D, Knapp, S, Knaus, P, Mathea, S, Preuss, F, Salah, E, Tumber, A   +10 more
core   +2 more sources

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that precedes the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Influence of the position and depth of pre-cutting kerfs on the rock breaking by SBM cutter

Meitan xuebao
The combination of water-jet and disc-cutter rock breaking is a key technology to improve the rock breaking efficiency of the full-face shaft boring machine and achieve the mechanized development of deep resources.
Renshu YANG, Yiqiang KANG, Liyun YANG, Kang LIU, Chenxi DING, Jinhao FAN   +5 more
doaj   +1 more source

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source