Results 31 to 40 of about 53,996 (266)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Study conical pick cutting performance and fatigue life in breaking rock plate process with numerical simulation

Scientific Reports
The fatigue life and cutting performance of conical pick is essential for the roadheader machine in the excavation engineering. In rock breaking process, the rock structural conditions has a certain influence on the rock breaking and rock damage with ...
Mingyan Wang
doaj   +1 more source

Energy Dissipation and Damage Evolution of Water-Saturated Skarn Under Impact Loading

Applied Sciences
Understanding the combined effects of water and dynamic disturbance on rock behavior is essential for deep underground engineering, where groundwater and blasting often coexist.
Ximing Jian, Pinzhe Zhao, Xianglong Li, Jianguo Wang, Yaohong Li, Yang Yang   +5 more
doaj   +1 more source

Study on the Damage Model of Coal Rock Caused by Hydraulic Pressure and Electrical Impulse in Borehole

Geofluids, 2021
The purpose of this study is to study the damage and fracturing effects of high-voltage discharge on coal-rock mass under the action of hydrostatic pressure. Based on the traditional damage evolution model and the change of the effective bearing area and
Xiankai Bao, Jiaxing Cao, Wenxiang Zheng, Junyu Guo, Yuan Liu, Jinchang Zhao   +5 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The Gap Rock Lighthouse: construction and typhoon damage

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2019
This paper focuses on the Gap Rock lighthouse, a legendary maritime infrastructure built 130 years ago in the Chinese territory and an early example of joint venture among the Qing Dynasty, the British Empire and the Hong Kong Colonial Government over a course of two decades.
K. Y. Deng, S. W. Poon
openaire   +3 more sources

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Numerical Simulation Analysis of Mechanical Properties on Rock Brittle–Ductility Transformation Under Different Loading Rates

Frontiers in Earth Science, 2022
At present, a large number of physical tests and numerical simulations have been carried out to study the effect of confining pressure on rock deformation mechanism, and some achievements have been achieved; however, the mechanism of rock deformation in ...
Zhichao Tian, Zhichao Tian, Chunan Tang, Chunan Tang, Chaoyun Yu, Yejiao Liu, Shijiang Chen, Yun Jin   +7 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source