Results 41 to 50 of about 53,996 (266)
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
Shock and Vibration, 2019 This paper aims to investigate the mechanics and damage properties of granite by drilling a center hole in Φ50 × 100 mm standard granite specimens under high-frequency constant impact load and then applying them to the uniaxial compression experiment ...
Zhi Liu +3 more
doaj +1 more source
Shock and Vibration, 2020 In blasting excavation of neighborhood tunnels, damage accumulation process in surrounding rock is inevitable. To explore the influence of damage accumulation of rock mass under multiple blasting loads, we analyzed the vibration damage accumulation ...
Feng Cao, Sheng Zhang, Tonghua Ling
doaj +1 more source
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley +1 more source
IEEE Access, 2018 Thermal-mechanical coupling damage is an important factor leading to instability and failure of rock mass engineering. The constitutive relation and damage evolution of rock-like materials under high strain rate is crucial parameters for the design of ...
Tubing Yin +3 more
doaj +1 more source
Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi +19 more
wiley +1 more source
Fracture Network Influence on Rock Damage and Gas Transport following an Underground Explosion
GeotechnicsSimulations of rock damage and gas transport following underground explosions that omit preexisting fracture networks in the subsurface cannot fully characterize the influence of geo-structural variability on gas transport.
Aidan Stansberry +6 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane +43 more
wiley +1 more source
Blast Induced Crack Propagation and Damage Accumulation in Rock Mass Containing Initial Damage
Shock and Vibration, 2018 Blast induced rock mass damage and crack propagation play important roles in structure safety and stability in mining, quarrying, and civil constructions.
Yixian Wang +5 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak +4 more
wiley +1 more source