Results 61 to 70 of about 32,671 (309)

Discontinuities in rock mass

, 2019
This chapter discusses the origin of discontinuities and explain how to identify and measure them in the field. It also discusses the effect of discontinuities on the rock mass properties of sandstone, mudstone and andesite at the project site.
Gratchev, Ivan, Ivan Gratchev
core   +1 more source

cnnImpute: missing value recovery for single cell RNA sequencing data

Scientific Reports
The advent of single-cell RNA sequencing (scRNA-seq) technology has revolutionized our ability to explore cellular diversity and unravel the complexities of intricate diseases.
Wenjuan Zhang, Brandon Huckaby, John Talburt, Sherman Weissman, Mary Qu Yang   +4 more
doaj   +1 more source

Correction to: Identification and characterization of conserved lncRNAs in human and rat brain

BMC Bioinformatics, 2018
After publication of the original article [1], it was noticed that the Acknowledgement statement was incorrect. The original statement reads:
Dan Li, Mary Qu Yang
doaj   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

A Numerical Study on Wave Transmission Across Multiple Intersecting Joint Sets in Rock Masses with UDEC

This paper presents a numerical study on wave transmission across jointed rock masses with UDEC, where multiple intersecting joint sets exist. The capability of UDEC of studying wave transmission across rock joints is validated through comparison with ...
Zhu, J. B., Deng, X. F., Zhao, J., Zhao, X. B.   +3 more
core   +1 more source

Research on the Deformation Law of Jointed Surrounding Rock during Tunnel Excavation Based on Hydromechanical Coupling

Geofluids, 2021
The coupling of the joint network and groundwater in rock under bias conditions has a significant impact on the deformation and failure of the surrounding rock due to tunnel excavation.
Yan Wang, Mingfei Li
doaj   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

A novel method for geometric quality assurance of rock joint replicas in direct shear testing – Part 1: Derivation of quality assurance parameters and geometric reproducibility

, 2023
Since each rock joint is unique by nature, the utilization of replicas in direct shear testing is required to carry out experimental parameter studies.
N.W. Portal, F. Johansson, Johnson, Erland,, Johnson, E.,, Flansbjer, M.,, Ivars, Diego Mas,, J. Larsson, M. Flansbjer, Johansson, Fredrik,, Portal, N. W.,, E. Johnson, Johansson, F.,, Flansbjer, Mathias,, Ivars, DM,, Larsson, Jörgen,, D. Mas Ivars, Williams Portal, Natalie,   +16 more
core   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Large‐Scale Genomics Reveals Three‐Source Ancestry and Layered Adaptation to High Altitude in Tibetan Chickens

Advanced Science, EarlyView.
Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...
Zongyi Zhao, Ruixue Nie, Hailu Fan, Tenzin Ngodroup, Li Zhu, Hongbin Pan, Bo Zhang, Hao Zhang   +7 more
wiley   +1 more source