Results 81 to 90 of about 464,941 (308)

Grip and Grasp: Lizard Claw Inspired Robotic Manipulators

open access: yesAdvanced Robotics Research, EarlyView.
Our study identifies the most effective lizard claw shape for use as an end effector in a bioinspired robotic manipulator. By examining key geometric features and combining them into comparative indices, the Crotaphytus collaris claw is found to be the best fit.
Hyeon Lee   +4 more
wiley   +1 more source

Recorded displacements in a landslide slope due to regional and teleseismic earthquakes [PDF]

open access: yes, 2015
Regional and teleseismic earthquakes can induce displacements along joints in a landslideinvolved rocky slope in Central Italy. The rarity of these effects is due to specific physical properties of the seismic signals associated with: (i) the energy ...
Lenti, L.   +4 more
core   +1 more source

The Transcription Factor FgSge1 Harnesses the SAGA Complex to Activate Mycotoxin Biosynthesis and Fungal Virulence

open access: yesAdvanced Science, EarlyView.
This study reveals the molecular mechanism by which the transcription factor FgSge1 regulates mycotoxin biosynthesis and virulence in Fusarium graminearum. FgSge1 binds to the TAARGTTT cis‐element, enabling self‐activation. It recruits the SAGA complex, promotes histone acetylation, and facilitates jet‐like chromatin remodeling, thereby activating ...
Yueqi Zhang   +6 more
wiley   +1 more source

Rock Joint Surfaces Measurement and Analysis of Aperture Distribution under Different Normal and Shear Loading Using GIS

open access: yes, 2008
Geometry of the rock joint is a governing factor for joint mechanical and hydraulic behavior. A new method of evaluating aperture distribution based on measurement of joint surfaces and three dimensional characteristics of each surface is developed ...
Esaki, Tetsuro   +2 more
core  

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

open access: yesAdvanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao   +12 more
wiley   +1 more source

Fractal model and Lattice Boltzmann Method for Characterization of Non-Darcy Flow in Rough Fractures. [PDF]

open access: yes, 2017
The irregular morphology of single rock fracture significantly influences subsurface fluid flow and gives rise to a complex and unsteady flow state that typically cannot be appropriately described using simple laws.
Chang, Chun   +4 more
core   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

open access: yesAdvanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang   +11 more
wiley   +1 more source

Study conical pick cutting performance and fatigue life in breaking rock plate process with numerical simulation

open access: yesScientific Reports
The fatigue life and cutting performance of conical pick is essential for the roadheader machine in the excavation engineering. In rock breaking process, the rock structural conditions has a certain influence on the rock breaking and rock damage with ...
Mingyan Wang
doaj   +1 more source

Shear Properties and Failure Mechanism of Matched Discontinuities Between Two Different Rock Types Under Direct Shear

open access: yesApplied Sciences
The shear mechanical properties of rock discontinuities with different joint wall compressive strengths are a practical basis for the stability analysis of layered rock mass.
Xiaobo Zhang   +4 more
doaj   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

open access: yesAdvanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang   +13 more
wiley   +1 more source

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