Results 71 to 80 of about 32,671 (309)

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

Crack coalescence in rock-like specimens with two dissimilar layers and pre-existing double parallel joints under uniaxial compression

, 2021
Layered rock masses with joints are widely found in nature. Their mechanical behavior plays a key role in rock engineering applications. However, previous studies have concentrated on the single lithologic layer, and few studies have reported the crack ...
Cao, Rihong,, Zhao, Zhiye,, Lin, Qibin,, Cao, Ping,, Meng, Jingjing,, Wen, Guanping,   +5 more
core   +1 more source

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, EarlyView.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

A method for graphically presenting the deformation modulus of jointed rock masses

, 2001
A method to graphically present the deformation modulus of jointed rock masses is presented. A global co-ordinate system is used in the approach to define the geometry of rock joints.
Li, Chunlin,
core   +1 more source

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, EarlyView.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source

Experimental Study on Wave Propagation Across a Rock Joint with Rough Surface

Joints are an important mechanical feature of rock masses. Their effect on wave propagation is significant in characterizing dynamic behaviors of discontinuous rock masses.
Li, J. C., Cai, M. F., Zou, Y., Chen, X., Zhao, J.   +4 more
core   +1 more source

A novel method for geometric quality assurance of rock joint replicas in direct shear testing – Part 2: Validation and mechanical replicability

, 2023
Each rock joint is unique by nature which means that utilization of replicas in direct shear tests is required in experimental parameter studies. However, a method to acquire knowledge about the ability of the replicas to imitate the shear mechanical ...
N.W. Portal, F. Johansson, E. Johnson, Johnson, Erland,, Johansson, F,, Ivars, D. Mas,, Flansbjer, Mathias,, J. Larsson, M. Flansbjer, Larsson, Jörgen,, D. Mas Ivars, Williams Portal, Natalie,   +11 more
core   +1 more source

Study conical pick cutting performance and fatigue life in breaking rock plate process with numerical simulation

Scientific Reports
The fatigue life and cutting performance of conical pick is essential for the roadheader machine in the excavation engineering. In rock breaking process, the rock structural conditions has a certain influence on the rock breaking and rock damage with ...
Mingyan Wang
doaj   +1 more source

Strain‐Preserving Transfer of Freestanding Oxide Membranes for Tunable Magnetic Anisotropy

Advanced Science, EarlyView.
An epoxy‐assisted exfoliation and transfer strategy circumvents the trade‐off between structural flexibility and strain tunability in freestanding oxide membranes. Epitaxial strain is effectively preserved, enabling versatile and robust control of magnetic anisotropy without sacrificing flexibility.
Jinfeng Zhang, Yuyue Zhao, Shouzhe Dong, Jingdi Lu, Qing Wang, Fang Xu, Ao Wang, Kunjie Dai, Yueming Huang, Zhengguo Liang, Qiming Lv, Houbing Huang, Wenbin Wu, Lingfei Wang   +13 more
wiley   +1 more source

The characterisation and analysis of in-situ and blasted block-size distributions and the blastability of rock masses.

, 1997
PhDIn this thesis, previous research on discontinuity geometry, in-situ block size distribution (IBSD), blasted block size distribution (BBSD), and blastability of rock mass is discussed.
Lu, Ping
core