Results 161 to 170 of about 310,553 (303)

Engineering an Optogenetic pH‐Modulator in Bacteria

Advanced Science, EarlyView.
ABSTRACT Cells in many naturally occurring organisms routinely cooperate to control their extracellular pH in a dynamic and reversible manner, but this capability has been underexplored in synthetic biology. Here, we sought to engineer a microbial system that switches between two states —high and low extracellular pH— with minimal human intervention ...
Jenevieve Kuang, Olivia J. Armendarez, Wei‐Ting Chang, Matthew M. Hausladen, Shanna Bonanno, Daniel J. Wilson, Neel S. Joshi, Leila F. Deravi   +7 more
wiley   +1 more source

Reconstructing subsurface fracture geometries in rock slope instabilities through ambient vibration-based numerical modelling inversion. [PDF]

Sci Rep
Grechi G, Moore JR, D'Amico S, Martino S.   +3 more
europepmc   +1 more source

A Dynamic 3D Human Liver Sinusoid Model for Mechanistic Interrogation of Fontan‐Associated Liver Disease

Advanced Science, EarlyView.
This study presents a perfusable 3D bioengineered liver sinusoid platform that integrates biofabrication, 3D cell culture, controlled hemodynamics, and multiparametric characterization to model Fontan‐associated liver disease. By decoupling pressure and hypoxia effects, the system reveals early mechanobiological and profibrotic responses under ...
Sarah Rezapourdamanab, Mehdi Salar Amoli, Tanmay Mukherjee, Maryam Bagheri, Boeun Hwang, Linqi Jin, Yamini Singh, Sophia Norton, Ashay Vishwas Bongirwar, Shweta Karnik, Lakshmi Prasad Dasi, Reza Avazmohammadi, Rene Romero, Holly D. Bauser‐Heaton, Vahid Serpooshan   +14 more
wiley   +1 more source

Method and application of stability prediction model for rock slope. [PDF]

Sci Rep
Qi Y, Bai C, Li X, Duan H, Wang W, Qi Q.
europepmc   +1 more source

MGDP: Mastering a Generalized Depth Perception Model for Quadruped Locomotion

Advanced Science, EarlyView.
ABSTRACT Perception‐based Deep Reinforcement Learning (DRL) controllers demonstrate impressive performance on challenging terrains. However, existing controllers still face core limitations, struggling to achieve both terrain generality and platform transferability, and are constrained by high computational overhead and sensitivity to sensor noise.
Yinzhao Dong, Ji Ma, Yidan Lu, Jiahui Zhang, Wanyue Li, Yeke Chen, Teng Zhang, Xuechao Chen, Zhangguo Yu, Peng Lu   +9 more
wiley   +1 more source

Intelligent construction method for rock slope fracture network model based on discrete element and neural network. [PDF]

Sci Rep
Zhang Z, Chen H, Wu H, Yang T, Li B, Teng H, Yang H.   +6 more
europepmc   +1 more source

Slope stability of the open pits-rock slope

, 2021
Sadiola Açık Altın Madenlerinde yamaçların stabilitesi, istikrarsızlıkların sahip olabileceği önemli zararlı sonuçlardan dolayı büyük bir endişe konusudur. Bu madenlerin güvenli ve sürekli ekonomik çalışmasını sağlamak için, şevlerin stabilite riskini sistematik olarak değerlendirmek ve yönetmek gereklidir.
openaire   +1 more source

Pyroptosis‐Inducing Engineered Microparticles for Cancer Immunotherapy

Advanced Science, EarlyView.
Engineered microparticles co‐delivering geldanamycin and dual nanobodies induce targeted pyroptosis and block PD‐L1 and CD47 pathways, reprogramming the tumor microenvironment and achieving potent antitumor immunity in lung cancer models with minimal toxicity.
Tianli Hao, Zihan Deng, Yufei Liu, Li Liu, Deqiang Deng, Muyang Yang, Yuanyuan Geng, Yao Sun, Beilei Yue, Jonathan F. Lovell, Yushuai Liu, Lisen Lu, Honglin Jin   +12 more
wiley   +1 more source

Prediction of potential shear slip surface in locked rock mass of gently inclined counter Tilted rock slope under mining effects. [PDF]

Sci Rep
Meng W, Dai Z, Luo Q, Bai H, Xia T, Cao Y.   +5 more
europepmc   +1 more source

Manipulating Atomic Disorder and Mesoscale Architectures for High‐Efficiency Thermoelectric Modules

Advanced Science, EarlyView.
The in situ reaction of PbTiO3 precursor reacts in situ with the Bi0.5Sb1.5Te3 matrix, effectively enlarging the energy barrier for minority carrier excitation and suppressing bipolar diffusion, and predominantly scattering mid‐to‐low frequency phonons. Ultimately, a single thermoelectric module was fabricated to achieve a competitive efficiency of ∼7%
Jiwu Xin, Bo Wang, Chengyun Xu, Wang Li, Pengyu Zhang, Dongwang Yang, Yongke Wang, Jinfeng Dong, Lei Wei, Ting Zhang, Qinghui Jiang   +10 more
wiley   +1 more source