Results 31 to 40 of about 49,534 (268)

Data-Driven Modeling of Peak Rotation and Tipping-Over Stability of Rocking Shallow Foundations Using Machine Learning Algorithms

Geotechnics, 2022
The objective of this study is to develop data-driven predictive models for peak rotation and factor of safety for tipping-over failure of rocking shallow foundations during earthquake loading using multiple nonlinear machine learning (ML) algorithms and
Sivapalan Gajan
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Dynamic Response of Ancient Dowel-Connected Multi-Drum Columns: A 3D Finite Element Study of Friction Effects

Buildings
The dynamic response of ancient multi-drum columns, commonly found in historical monuments, is characterized by complex nonlinear mechanisms including rocking, sliding, and wobbling.
Olympia K. Panagouli, Maria Kafetsi
doaj   +1 more source

Performance of rocking systems on shallow improved sand: Shaking table testing

Frontiers in Built Environment, 2015
Recent studies have highlighted the potential benefits of inelastic foundation response during seismic shaking. According to an emerging seismic design scheme, termed rocking isolation, the foundation is intentionally under–designed to promote rocking ...
Angelos eTsatsis, Ioannis eAnastasopoulos   +1 more
doaj   +1 more source

MOBILE INFORMATION SYSTEM PENDATAAN HASIL PENGOLAHAN BIJI TIMAH DENGAN ALAT MEJA GOYANG PADA PT TIMAH TBK

Jurnal Sisfokom, 2021
The high demand for tin mining commodities has pushed the development of mining product processing technology quite significantly. However, the more difficult it is to obtain available reserves and the lower the processed Tin content, the lower the ...
Anisah, Herfani Tri Nurpebri, Sarwindah, Yurindra   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

A method for optimizing and controlling rocking drillstring–assisted slide drilling

Natural Gas Industry B
Rocking the drillstring at the surface during slide drilling is a common method for reducing drag when drilling horizontal wells. However, the current methods for determining the parameters for rocking are insufficient, limiting the widespread use of ...
Yabin Zhang, Jian Lu, Binfeng Guo, Xueying Wang, Feifei Zhang   +4 more
doaj   +1 more source

Rock's pill that rocked the world

South African Medical Journal, 2010
I was a rookie doctor on the goldmines in the early 1960s. Part of my duties was to look after the families in the villages of the Anglo American mines at Welkom in the Free State. Their invariably large numbers of children prompted me to enquire whether they wished to have assistance in family planning.
openaire   +3 more sources

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source