Results 41 to 50 of about 30,184 (267)
Influence of Rocking Shallow Foundation Parameters and Analysis of Seismic Response Characteristics
BuildingsRocking shallow foundations interrupt the seismic transmission path from the base of the structure and possess advantages, such as effective seismic isolation, self-resetting capabilities post-earthquake, and low costs.
Jia Bin +4 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane +43 more
wiley +1 more source
Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito +8 more
wiley +1 more source
Multimodal Data‐Driven Microstructure Characterization
Advanced Engineering Materials, EarlyView.A self‐consistent autonomous workflow for EBSP‐based microstructure segmentation by integrating PCA, GMM clustering, and cNMF with information‐theoretic parameter selection, requiring no user input. An optimal ROI size related to characteristic grain size is identified.
Qi Zhang +4 more
wiley +1 more source
A Dislocation Perspective on Strength and Toughness in Ceramics
Advanced Engineering Materials, EarlyView.Dislocations in ceramics enjoy a long but yet under‐appreciated history. The three research waves for dislocations in ceramics highlight the topic evolution over the last 90 years. This review focuses on the impact of dislocation on strength and toughness in ceramics.
Xufei Fang
wiley +1 more source
Applied SciencesThe transportation of freestanding packages, such as steel coils and prefabricated building components, poses significant safety challenges due to their susceptibility to dynamic responses like rocking, sliding, and overturning under vehicle acceleration.
Zhenmin Qi, Dapeng Zhu
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Advances in Civil Engineering, 2019 In this study, a series of shaking table tests were conducted using a specimen that consisted of a superstructure, incorporating a friction device and a sway-rocking mechanism under the superstructure to determine the optimal damper slip force of a ...
Kazutaka Shirai +3 more
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Advanced Functional Materials, EarlyView.A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo +7 more
wiley +1 more source
Advanced Functional Materials, EarlyView.An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández +14 more
wiley +1 more source
BuildingsReinforced concrete (RC) structural walls are essential for ensuring adequate lateral stiffness and strength in buildings located in seismic regions. However, many older structures incorporate nonconforming walls constructed with low-strength concrete ...
Yusuf Şahinkaya +3 more
doaj +1 more source