Results 181 to 190 of about 6,500 (214)

Nucleotide sequence of the canine rod-opsin-encoding gene

Gene, 1994
The major parts of two canine rod-specific opsin (Ops) transcripts have been cloned by polymerase chain reaction from retinal mRNA. Both transcripts are derived from the same gene. The 5' leader sequence of the transcripts was cloned from canine peripheral blood DNA.
S M, Petersen-Jones, A K, Sohal, D R, Sargan   +2 more
openaire   +2 more sources

Structural aspects of rod opsin and their implication in genetic diseases

Pflügers Archiv - European Journal of Physiology, 2021
Vision in dim-light conditions is triggered by photoactivation of rhodopsin, the visual pigment of rod photoreceptor cells. Rhodopsin is made of a protein, the G protein coupled receptor (GPCR) opsin, and the chromophore 11-cis-retinal. Vertebrate rod opsin is the GPCR best characterized at the atomic level of detail.
Fanelli F., Felline A., Marigo V.
openaire   +2 more sources

Time course of opsin expression in developing rod photoreceptors

Development, 1990
Abstract We have investigated the time course of rod photoreceptor determination in the goldfish retina. Rod precursor cells located in the outer nuclear layer of the mature retina continuously generate rod photoreceptors. In this study, we asked when rod precursor cells begin to express opsin, which would signal their commitment to the ...
J K, Knight, P A, Raymond
openaire   +2 more sources

Embryonic appearance of rod opsin in the urodele amphibian eye

Roux's Archives of Developmental Biology, 1993
Notophthalmus (Triturus) viridescens, a urodele amphibian (newt) common to the Eastern United States, is a promising subject for developmental and regeneration studies. We have available a monoclonal antibody shown to be specific in many vertebrates for rod opsin, the membrane apoprotein of the visual pigment rhodopsin.
David Stephen, McDevitt, Samir Kumar, Brahma, Jean-Claude, Jeanny   +2 more
openaire   +2 more sources

Rod phototransduction in transgenic mice expressing a mutant opsin gene

Journal of the Optical Society of America A, 1996
Rod-mediated electroretinograms (ERG's) were recorded from transgenic mice expressing a mouse opsin gene with three point mutations (V20G, P23H, and P27L; termed VPP mice) and from normal littermates. The leading edge of the alpha wave was analyzed in relation to a computational model of rod phototransduction [J. Physiol.
Y, Goto, N S, Peachey, N E, Ziroli, W H, Seiple, C, Gryczan, D R, Pepperberg, M I, Naash   +6 more
openaire   +2 more sources

Circadian rhythm and light regulate opsin mRNA in rod photoreceptors

Nature, 1989
Disk membranes in the outer segment of rod photoreceptors are continuously renewed, being assembled at the outer segment base, displaced outward by new disks and eventually shed at the tip. In lower vertebrates, disk assembly occurs with a diurnal rhythm with 2-4% of the outer segment length produced daily.
J I, Korenbrot, R D, Fernald
openaire   +2 more sources

Isolation and coding sequence of the rat rod opsin gene

Journal of Molecular Neuroscience, 1994
The phototransduction cascade in vertebrate rod and cone photoreceptors is initiated by a light-induced conformational change in the visual pigment rhodopsin. The visual pigments are members of the seven-transmembrane domain, G-protein coupled receptor superfamily and consist of an apoprotein, opsin, and a chromophore, 11-cis-retinal.
C J, Barnstable, M A, Morabito
openaire   +2 more sources

Structure and evolution of the Teleost extraretinal rod‐like opsin (errlo) and ocular rod opsin (rho) genes: Is teleost rho a retrogene?

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 2003
AbstractIn Teleost fish examined to date the ocular rod opsin gene, rho, is intronless, unlike the rod opsin genes of other vertebrate classes which possess a five exon/four intron structure. We have examined in silico the structure of rho (which is expressed uniquely in the retina) and the closely related extraretinal rod‐like opsin (exo‐rhodopsin ...
Bellingham, James, Tarttelin, Emma E., Foster, Russell G., Wells, Dominic J.   +3 more
openaire   +3 more sources

Codistribution of S-antigen and opsin in light-adapted retinal rods

Documenta Ophthalmologica, 1986
The localization of S-antigen in ultra-cryosections of rat retina has been studied and compared with that of opsin by immunoelectron microscopy. Monospecific antisera to both proteins, and Protein A-coated gold particles of two sizes were used for (double) labeling.
R M, Broekhuyse, E D, Kuhlmann, L J, Leunissen, H M, van de Scheur, A J, Verkleij   +4 more
openaire   +2 more sources

Development of a Cellular Model of Rod Opsin Retinitis Pigmentosa

2011
A cellular model was developed to investigate potential mechanisms of cell death in rod opsin retinitis pigmentosa (RP). This model is based on transient expression of the WT and mutant P23H rod opsin in human retinal pigmented epithelial cells (RPE). Cells expressing mutant P23H opsin, unlike those expressing WT opsin, have altered opsin trafficking ...
Matthew, Adamowicz, Antonius, Song, Samuel, Wadsworth, Abraham, Scaria, Catherine, O'Riordan   +4 more
openaire   +2 more sources