Results 271 to 280 of about 10,821,016 (340)

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source

The 90th anniversary of Angiostrongylus cantonensis: from local discovery to global endemic. [PDF]

Infect Dis Poverty
Lv S, Zhou XN.
europepmc   +1 more source

The characteristics of collagen‐induced rheumatoid arthritis in macaques and the changes of heart

Animal Models and Experimental Medicine, EarlyView.
The disease progression in CIA macaques was categorized into three stages: IIR (days 14–34): The indicators related to rheumatoid arthritis and the levels of immunoglobulin were all elevated. There was a small amount of joint effusion, edema and mild synovial hyperplasia. No joint swelling was observed by naked eye.
Lei Zhang, Haifeng Jiang, Zhen Xu, Tingyu Dong, Xiaoyi Liu, Shangxue Yan, Jiajie Kuai, Yan Chang, Wei Wei   +8 more
wiley   +1 more source

Distribution and Risk Factors of Scrub Typhus in South Korea, From 2013 to 2019: Bayesian Spatiotemporal Analysis. [PDF]

JMIR Public Health Surveill
Kim J, Vounatsou P, Chun BC.
europepmc   +1 more source

Nagetiere und Nagetierassoziierte Krankheitserreger (Rodents and rodent associated disease pathogen)

, 2009
Ulrich, RG, Heckel, Gerald, Pelz, HJ, Wieler, LH, Nordhoff, M., Dobler, G., Freise, J., Matuschka, FR, Jacob, J., Schmidt-Chanasit, J., Gerstengarbe, FW, Jaekel, T., Suess, J., Ehlers, B., Nitsche, A., Kallies, R., Johne, R., Guenther, S., Henning, K., Grunow, R., Wenk, W., Maul, LC, Hunfeld, KP, Woelfel, R., Schares, G., Scholz, HC, Brockmann, SO, Pfeffer, M., Essbauer, SS   +28 more
openaire   +2 more sources

Establishment of a chronic aspiration pneumonia mouse model using oropharyngeal aspiration of food suspension

Animal Models and Experimental Medicine, EarlyView.
Four aspiration methods (UV, IN, IT, and OA) were compared, and OA was identified as the most effective delivery technique. A chronic aspiration pneumonia model was then established through repeated OA of food suspension or gastric contents. Integrated analyses, including micro‐CT, histopathology, cytokine profiling, and RNA sequencing, revealed ...
Qianwen Li, Fansen Lin, Hongzhi Gao, Yun Zhao, Yuqi Liu   +4 more
wiley   +1 more source

Mosquito seasonality and trap type evaluation using routine surveillance data from New Orleans, Louisiana, United States. [PDF]

PLoS One
Scavo NA, Reyes D, Pavlakis AF, Riegel C, Wilke ABB.   +4 more
europepmc   +1 more source

Conditioning Electrical Stimulation for Patients with Moderate or Severe Carpal Tunnel Syndrome: Double Blinded Randomized Controlled Trial

Annals of Neurology, EarlyView.
Objective Carpal tunnel syndrome (CTS) can drastically impair one's ability to work and interferes with activities of daily living. We recently demonstrated that, in rodents, conditioning electrical stimulation (CES) delivered to the nerve 7 days prior to surgery imparts a conditioning lesion‐like effect by accelerating the rate of regeneration along ...
Yusuke Osaki, Jaret L. Olson, Michael J. Morhart, Matthew W. Curran, Douglas W. Zochodne, K. Ming Chan, on behalf of the Central and Northern Alberta Peripheral Nerve Injury Research Consortium, Hollie Power, Adil Ladak, Lindsay Hubenig, Alto Lo, Christine Webber, Karyne Rabey, Andrew Jack, Joe Watt, Mithun Rajshekar, Ellen Lee, Glyn Murgatroyd, Dan Yeung, Kathleen O'Grady   +19 more
wiley   +1 more source

Land use gradients drive spatial variation in Lassa fever host communities in the Eastern Province of Sierra Leone. [PDF]

J Anim Ecol
Simons D, Gibb R, Bangura U, Sondufu D, Lamin J, Koninga J, Foday M, Dawson M, Lahai J, Ansumana R, Fichet-Calvet E, Watson-Jones D, Kock R, Jones KE.   +13 more
europepmc   +1 more source