Results 271 to 280 of about 9,520,639 (370)

FBXO2 Alleviates Intervertebral Disc Degeneration via Dual Mechanisms: Activating PINK1‐Parkin Mitophagy and Ubiquitinating LCN2 to Suppress Ferroptosis

Advanced Science, EarlyView.
F‐box only protein 2 (FBXO2) combats intervertebral disc degeneration (IVDD) by coordinating dual protection. It activates PTEN‐induced putative kinase 1 (PINK1)‐Parkin mitophagy restoring mitochondrial function and targets lipocalin‐2 (LCN2) for degradation, suppressing ferroptosis.
Tongde Wu, Yanjin Wang, Beiduo Shen, Kai Guo, Ziqi Zhu, Yongzhou Liang, Jianhua Zeng, Desheng Wu   +7 more
wiley   +1 more source

Prevalence and genetic diversity of Babesia microti in rodents from central and southern Shanxi, China. [PDF]

Parasit Vectors
Ren F, Liu Y, Niu J, Song Y, Cheng H, Zhao C, Cui J, Chen Y, Bai Y, Rao H, Yu J.   +10 more
europepmc   +1 more source

Disease Problems of Small Rodents

, 2012
Cynthia Brown, Thomas M. Donnelly
openaire   +2 more sources

PD‐L1‐Targeting Biomimetic Photoresponsive Thermosensitive Liposomes for Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Tan et al. developed a platelet membrane‐coated, thermoresponsive liposome for targeted, light‐controlled delivery of fluorinated peptides that promotes programmed death‐ligand 1 degradation, induces tumor immunogenic cell death, suppresses solid tumors and metastases, and triggers durable immune memory, offering a promising strategy for peptide‐based ...
Manman Tan, Chengyu Shi, Guangyi Chi, Xinwan Su, Fangzhou Liu, Linyu Zhu, Guangqian Cheng, Xiangyi Chen, Meng Yu, Yijian Chen, Ying Wang, Yu Chen, ShuLing Yan, Wenfei Wu, Qingfeng Yan, Jianzhong Shao, Kai Wang, Xiangrui Liu, Min Zhou, Aifu Lin   +19 more
wiley   +1 more source

Estimation of Lassa fever incidence rates in West Africa: Development of a modeling framework to inform vaccine trial design. [PDF]

PLoS Negl Trop Dis
Moore SM, Rapheal E, Mendoza Guerrero S, Dean NE, Stoddard ST.   +4 more
europepmc   +1 more source

Neurological approaches for investigating West Nile virus disease and its treatment in rodents

, 2013
John D. Morrey, Venkatraman Siddharthan, Hong Wang   +2 more
openalex   +1 more source

Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models

Advanced Science, EarlyView.
Rapamycin alleviates heart failure via TFEB and CaMKII pathways in Syntaxin 12/13 deficient models. Stx12 deficiency causes heart failure via impaired iron trafficking to mitochondria, reducing respiratory complexes and sarcoplasmic reticulum Ca2+‐ATPase (SERCA).
Run‐Zhou Yang, Fang Li, Jiao Liu, Shu‐Ang Li, Dan‐Hua Liu, Zhuanbin Wu, Pei‐Pei Liu, Wenju Liu, Bin Zhou, Cizhong Jiang, Haibing Zhang, Ying Yu, Jian‐Sheng Kang   +12 more
wiley   +1 more source

Climate differentially impacts ticks infected and uninfected with <i>Borrelia burgdorferi</i>. [PDF]

Sci Adv
Broughton H, Crews A, Lilly M, Sambado S, Salomon J, Lawrence A, Ring K, Clark J, Shaw G, Summers S, Nakano A, Swei A.   +11 more
europepmc   +1 more source

Targeting the endothelial progenitor cell surface proteome to identify novel mechanisms that mediate angiogenic efficacy in a rodent model of vascular disease

, 2013
Catherine C. Kaczorowski, Timothy J. Stodola, Brian Hoffmann, Anthony R. Prisco, Pengyuan Y. Liu, Daniela N. Didier, Jamie R. Karcher, Mingyu Liang, Howard J. Jacob, Andrew S. Greene   +9 more
openalex   +2 more sources

Directed Self‐Assembly of Magnetic Bioceramic Deep Inside Dentinal Tubules May Alleviate Dental Hypersensitivity

Advanced Science, EarlyView.
Magnetically guided bioceramic nanoparticles (“CalBots”) achieve deep dentinal tubule occlusion via directed self‐assembly under externally applied magnetic field. Various visualization techniques and a novel mouse behavioral assay indicate that CalBot‐induced plugs may reduce dentinal sensitivity, offering a promising strategy for future dentin ...
Shanmukh Peddi, Prajwal Hegde, Prannay Reddy, Anaxee Barman, Arnab Barik, Debayan Dasgupta, Ambarish Ghosh   +6 more
wiley   +1 more source