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Overview on Rodent Models of Alzheimer's Disease
Current Protocols in Neuroscience, 2005AbstractIn Alzheimer's disease (AD), characteristic lesions develop in brain regions that subserve cognitive functions, ultimately leading to dementia. There are now several lesioned or transgenic small‐animal models of the disease that model select aspects of cognitive deficits and/or recapitulate many, but not all, of the characteristic pathologic ...
Jean-Cosme, Dodart, Patrick, May
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Pharmacological Models of Parkinson’s Disease in Rodents
2011Parkinson's disease (PD) is one of the most common neurodegenerative disorders. Despite the substantial progress that has been achieved, the precise mechanisms involved in the development of this disease are still not fully understood. The most common concepts relate to the genetic background and environmental/toxic effects.
Peter, Klivenyi, Laszlo, Vecsei
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In Practice, 2010
Pet rodents make up a small but significant part of the caseload in small animal veterinary practice. Skin disease is a frequent reason for presentation, as it is easily noticed by the owner, even in species that are not regularly handled. Particular problems encountered with the diagnosis and treatment of skin disease in rodents include the stress of ...
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Pet rodents make up a small but significant part of the caseload in small animal veterinary practice. Skin disease is a frequent reason for presentation, as it is easily noticed by the owner, even in species that are not regularly handled. Particular problems encountered with the diagnosis and treatment of skin disease in rodents include the stress of ...
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Cortical Plasticity in Alzheimer’s Disease in Humans and Rodents
Biological Psychiatry, 2007The aim of this study was to determine whether neocortical long-term potentiation (LTP) is deficient in patients with Alzheimer's disease (AD) and in amyloid precursor protein (APP)/presenilin-1 (PS1) mice, an AD animal model. We then ascertained whether this deficit might be paralleled by functional abnormalities of N-methyl-D-aspartate (NMDAR ...
BATTAGLIA F +6 more
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Neurological Diseases of Rabbits and Rodents
Journal of Exotic Pet Medicine, 2015Clinical signs of neurological disease, such as head tilt, hind limb paresis or paralysis, seizures, and muscle weakness, are commonly encountered in pet rabbits, and in the authors׳ experience, less often in rodent species. Moreover, localisation of neurological lesions and establishment of a definitive diagnosis can be challenging for any of the ...
Anna L. Meredith, Jenna Richardson
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Genetic Rodent Models of Huntington Disease
2018The monogenic nature of Huntington disease (HD) has led to the development of a spectrum of useful genetically modified models. In particular, rodents have pioneered as the first HD model being generated and have since been the most widely used animal model for HD in both basic research and preclinical therapeutic studies.
J, Stricker-Shaver +3 more
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Protozoal diseases of rabbits and rodents
Seminars in Avian and Exotic Pet Medicine, 1995Protozoal parasites have been reported in rabbits and a variety of rodents. In many cases, the organisms are coincidental commensals, and no disease is present. In others, protozoa may cause problems as secondary invaders in debilitated/immunocompromised hosts or as primary pathogens.
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Rodents in Relation to Disease and Their Control
Journal of the Royal Army Medical Corps, 1949openaire +2 more sources