Results 31 to 40 of about 9,442,226 (387)
The microbiome and rodent models of immune mediated diseases
Mammalian Genome, 2021 Over the last six decades production of laboratory rodents have been refined with the aim of eliminating all pathogens, which could influence research results. This has, however, also created rodents with little diversity in their microbiota.
A. K. Hansen, C. H. Hansen
semanticscholar +1 more source
Journal of Public Health in Africa, 2023 In addition to their economic significance, rodents are hosts and transmit diseases. Most of rodent-borne diseases are endemic in rural Africa and sporadically lead to epidemics.
Amina Issae +4 more
doaj +1 more source
Modeling Parkinson’s Disease: Not Only Rodents? [PDF]
Frontiers in Aging Neuroscience, 2021 Parkinson’s disease (PD) is a common chronic progressive multifactorial neurodegenerative disease. In most cases, PD develops as a sporadic idiopathic disease. However, in 10%–15% of all patients, Mendelian inheritance of the disease is observed in an autosomal dominant or autosomal recessive manner.
Petr A. Slominsky, Maria I. Shadrina
openaire +4 more sources
Scientific Reports, 2021 Zoonotic diseases, caused by pathogens transmitted between other vertebrate animals and humans, pose a major risk to human health. Rodents are important reservoir hosts for many zoonotic pathogens, and rodent population dynamics affect the infection ...
Mahdi Aminikhah +7 more
doaj +1 more source
Modeling Parkinson’s disease in LRRK2 rodents
Neuronal Signaling, 2023 Abstract Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with familial and sporadic forms of Parkinson’s disease (PD). Sporadic PD and LRRK2 PD share main clinical and neuropathological features, namely hypokinesia, degeneration of nigro-striatal dopamine neurons and α-synuclein aggregates in the form of Lewy ...
Domenicale, Chiara +2 more
openaire +3 more sources
Rodent Models of Huntington’s Disease: An Overview
Biomedicines, 2023 Huntington’s disease (HD) is an autosomal-dominant inherited neurological disorder caused by a genetic mutation in the IT15 gene. This neurodegenerative disorder is caused by a polyglutamine repeat expansion mutation in the widely expressed huntingtin (HTT) protein.
Giulio Nittari +7 more
openaire +4 more sources
Consequences of nano and microplastic exposure in rodent models: the known and unknown
Particle and Fibre Toxicology, 2022 The ubiquitous nature of micro- (MP) and nanoplastics (NP) is a growing environmental concern. However, their potential impact on human health remains unknown.
W. A. da Silva Brito +5 more
semanticscholar +1 more source
Bacterial and viral rodent-borne infections on poultry farms. An attempt at a systematic review
Journal of Veterinary Research, 2023 Rodents are quite common at livestock production sites. Their adaptability, high reproductive capacity and omnivorousness make them apt to become a source of disease transmission to humans and animals.
Domanska-Blicharz Katarzyna +3 more
doaj +1 more source
Uncovering sex differences of rodent microglia
Journal of Neuroinflammation, 2021 There are inherent structural and functional differences in the central nervous systems (CNS) of females and males. It has been gradually established that these sex-specific differences are due to a spectrum of genetic, epigenetic, and hormonal factors ...
Jinming Han +4 more
semanticscholar +1 more source
Scientific Reports, 2022 Rodents living alongside humans increases the probability of encounter and also the transmission of rodent-borne diseases. Singapore’s cosmopolitan urban landscape provides a perfect setting to study the prevalence of four rodent-borne pathogens: Seoul ...
Jane Griffiths +8 more
doaj +1 more source