Results 81 to 90 of about 10,821,016 (340)
Use of large animal models to investigate Huntington's diseases
Cell Regeneration, 2019 Animal models that can mimic human diseases are the important tools for investigating the pathogenesis of the diseases and finding a way for treatment.
Sen Yan, Shihua Li, Xiao-Jiang Li
doaj +1 more source
Metagenomic analysis of viromes in tissues of wild Qinghai vole from the eastern Tibetan Plateau
Scientific Reports, 2022 Rodents are natural reservoirs of diverse zoonotic viruses and widely distributed on the Tibetan Plateau. A comprehensive understanding of the virome in local rodent species could provide baseline of viral content and assist in efforts to reduce the risk
Xiaozhou He +9 more
doaj +1 more source
Hepatic progenitor cells from adult human livers for cell transplantation. [PDF]
, 2008 Objective: Liver regeneration is mainly based on cellular self-renewal including progenitor cells. Efforts have been made to harness this potential for cell transplantation, but shortage of hepatocytes and premature differentiated progenitor cells ...
Aurich, H. +10 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela +13 more
wiley +1 more source
Rodent models for the analysis of tissue clock function in metabolic rhythms research [PDF]
, 2017 The circadian timing system consists on a distributed network of cellular clocks that together coordinate 24-h rhythms of physiology and behavior. Clock function and metabolism are tightly coupled, from the cellular to the organismal level.
Astiz, Mariana +3 more
core +2 more sources
Rodent models in neuroscience research: is it a rat race?
Disease Models & Mechanisms, 2016 Rodents (especially Mus musculus and Rattus norvegicus) have been the most widely used models in biomedical research for many years. A notable shift has taken place over the last two decades, with mice taking a more and more prominent role in biomedical ...
B. Ellenbroek, J. Youn
semanticscholar +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman +9 more
wiley +1 more source
Veterinarski Glasnik, 2019 Background. Rodent pests are natural reservoirs and vectors of a vast array of human and animal diseases caused by bacteria, rickettsia, viruses, protozoans, fungi and some parasites. The most important risk factor for human infection with Trichinella is
Janković Ljiljana +6 more
doaj +1 more source
Rodent models for Alzheimer’s disease drug discovery [PDF]
Expert Opinion on Drug Discovery, 2015 Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss and personality changes, leading to dementia. Histopathological hallmarks are represented by aggregates of beta-amyloid peptide (Aβ) in senile plaques and deposition of hyperphosphorylated tau protein in neurofibrillary tangles in the brain.
PUZZO, DANIELA +3 more
openaire +2 more sources
Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett +8 more
wiley +1 more source