Results 41 to 50 of about 2,506,343 (333)

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Genetic variation in PTPN1 contributes to metabolic adaptation to high-altitude hypoxia in Tibetan migratory locusts

Nature Communications, 2018
Vertebrate adaptation to high-altitude life has been extensively investigated, while invertebrates are less well-studied. Here, the authors find signals of adaptive evolution in genomes of migratory locusts from the Tibetan Plateau, and implicate a PTPN1
Ding Ding, Guangjian Liu, Li Hou, Wanying Gui, Bing Chen, Le Kang   +5 more
doaj   +1 more source

Gut Microbiota is Associated with Aging‐Related Processes of a Small Mammal Species under High‐Density Crowding Stress

Advanced Science, 2023
Humans and animals frequently encounter high‐density crowding stress, which may accelerate their aging processes; however, the roles of gut microbiota in the regulation of aging‐related processes under high‐density crowding stress remain unclear.
Xiaoming Xu, Guoliang Li, Da Zhang, Hanyi Zhu, Guang‐hui Liu, Zhibin Zhang   +5 more
doaj   +1 more source

Prevalence and co-infection of Toxoplasma gondii and Neospora caninum in Apodemus sylvaticus in an area relatively free of cats [PDF]

, 2011
The protozoan parasite Toxoplasma gondii is prevalent worldwide and can infect a remarkably wide range of hosts despite felids being the only definitive host.
A. P. COX, D. THOMASSON, Dubey, Dubey, E. A. WRIGHT, Franti, G. HIDE, Hejlicek, Hide, J. M. HUGHES, Jacobs, K. BOYCE, M. ABUSHAHMA, M. T. ROGAN, N. S. DODD, O. GERWASH, R. G. MURPHY, Z.-R. LUN   +17 more
core   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Comparative Chromosome Maps of Neotropical Rodents Necromys lasiurus and Thaptomys nigrita (Cricetidae) Established by ZOO-FISH [PDF]

, 2011
This work presents chromosome homology maps between Mus musculus (MMU) and 2 South American rodent species from the Cricetidae group: Necromys lasiurus (NLA, 2n = 34) and Thaptomys nigrita (TNI, 2n = 52), established by ZOO-FISH using mouse chromosome ...
Diaz GB, D’Élia G, D’Élia G, Engelbrecht A, Fagundes V, Ford CE, Gallardo MH, Geise L, Hass I, I. Hass, I.J. Sbalqueiro, Matsubara K, Matsubara K, Musser GG, Nakamura T, R.F. Artoni, Rambau RV, Reig OA, Romanenko SA, S. Müller, Sbalqueiro IJ, Seabright M, Silva MJ, Smith MF, Smith MF, Stanyon R, Ventura K, Ventura K, Yang F   +28 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Subchronic Exposure to Low-Dose Chlorfenapyr and Emamectin Benzoate Disrupts Kidney Metabolism in Rats

Toxics
Residues of the pesticides chlorfenapyr (CFP) and emamectin benzoate (EMB) often coexist in the environment and can be accumulated in the body. To understand the impact of these two chemicals on health, we investigated their effect on the kidneys.
Di Zhang, Xiao-Hua Song, Dan Yang, Mu-Zi Ge, Jun Qiu, Han-Qing Jiang, Yan-Yan Sun, Xiang-dong Li, Yi-Jun Wu   +8 more
doaj   +1 more source

Correction to: Huddling remodels gut microbiota to reduce energy requirements in a small mammal species during cold exposure

Microbiome, 2018
Following publication of the original article [1], the authors reported an error in the caption of Fig. 4.
Xue-Ying Zhang, Gansukh Sukhchuluun, Ting-Bei Bo, Qing-Sheng Chi, Jun-Jie Yang, Bin Chen, Lei Zhang, De-Hua Wang   +7 more
doaj   +1 more source

Role of rodents in transmission of Salmonella and Campylobacter [PDF]

, 2007
Salmonella and Campylobacter are generally regarded as the most important food-borne pathogens in the world. Reduction or elimination of these pathogens in the first part of the food chain (on the farm) is important to prevent disease among consumers of ...
Kijlstra, Prof dr A, Meerburg, Dr BG
core