Results 41 to 50 of about 2,659,769 (337)

Clinical Management of Pain in Rodents.

Comparative medicine, 2019
The use of effective regimens for mitigating pain remain underutilized in research rodents despite the general acceptance of both the ethical imperative and regulatory requirements intended to maximize animal welfare.
P. Foley, L. Kendall, P. Turner
semanticscholar   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Parental experiences orchestrate locust egg hatching synchrony by regulating nuclear export of precursor miRNA

Nature Communications
Parental experiences can affect the phenotypic plasticity of offspring. In locusts, the population density that adults experience regulates the number and hatching synchrony of their eggs, contributing to locust outbreaks.
Ya′nan Zhu, Jing He, Jiawen Wang, Wei Guo, Hongran Liu, Zhuoran Song, Le Kang   +6 more
doaj   +1 more source

Rice stripe virus-derived siRNAs play different regulatory roles in rice and in the insect vector Laodelphax striatellus

BMC Plant Biology, 2018
Background Most plant viruses depend on vector insects for transmission. Upon viral infection, virus-derived small interfering RNAs (vsiRNAs) can target both viral and host transcripts.
Meiling Yang, Zhongtian Xu, Wan Zhao, Qing Liu, Qiong Li, Lu Lu, Renyi Liu, Xiaoming Zhang, Feng Cui   +8 more
doaj   +1 more source

Mammals of Southwestern Arkansas Part II. Rodents [PDF]

, 1989
This study investigated the composition and habitat affinities of the mammalian fauna of southwestern Arkansas. The study area was comprised of the 21 counties located south and/or west of and including Pulaski County.
England, Daniel R., McDaniel, V. Rick, Steward, Tim W.   +2 more
core   +2 more sources

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Genetic variation in PTPN1 contributes to metabolic adaptation to high-altitude hypoxia in Tibetan migratory locusts

Nature Communications, 2018
Vertebrate adaptation to high-altitude life has been extensively investigated, while invertebrates are less well-studied. Here, the authors find signals of adaptive evolution in genomes of migratory locusts from the Tibetan Plateau, and implicate a PTPN1
Ding Ding, Guangjian Liu, Li Hou, Wanying Gui, Bing Chen, Le Kang   +5 more
doaj   +1 more source

The Role of RFamide-Related Peptide-3 in Age-Related Reproductive Decline in Female Rats. [PDF]

, 2016
Reproductive senescence, the point in time when females cease to show estrous cyclicity, is associated with endocrine changes in the hypothalamus, pituitary, and gonads. However, the mechanisms triggering this transition are not well understood.
Bentley, George E, Geraghty, Anna C, Kaufer, Daniela, Kriegsfeld, Lance J, Muroy, Sandra E   +4 more
core   +1 more source

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

FEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera, Camille C. Caldeira da Silva, Maiza Von Dentz, Mauricio S. Baptista, Alicia J. Kowaltowski   +4 more
wiley   +1 more source

The accumulation of modular serine protease mediated by a novel circRNA sponging miRNA increases Aedes aegypti immunity to fungus

BMC Biology
Background Mosquitoes transmit many infectious diseases that affect human health. The fungus Beauveria bassiana is a biological pesticide that is pathogenic to mosquitoes but harmless to the environment.
Tengfei Lu, Yannan Ji, Mengmeng Chang, Xiaoming Zhang, Yanhong Wang, Zhen Zou   +5 more
doaj   +1 more source