Results 51 to 60 of about 102,516 (255)

Gut Microbiota is Associated with Aging‐Related Processes of a Small Mammal Species under High‐Density Crowding Stress

Advanced Science, 2023
Humans and animals frequently encounter high‐density crowding stress, which may accelerate their aging processes; however, the roles of gut microbiota in the regulation of aging‐related processes under high‐density crowding stress remain unclear.
Xiaoming Xu, Guoliang Li, Da Zhang, Hanyi Zhu, Guang‐hui Liu, Zhibin Zhang   +5 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

CRISPR/Cas9-mediated genome editing induces exon skipping by complete or stochastic altering splicing in the migratory locust

BMC Biotechnology, 2018
Background The CRISPR/Cas9 system has been widely used to generate gene knockout/knockin models by inducing frameshift mutants in cell lines and organisms.
Dafeng Chen, Ji-Xin Tang, Beibei Li, Li Hou, Xianhui Wang, Le Kang   +5 more
doaj   +1 more source

OF RODENTS AND HUMANS

, 2023
OF RODENTS AND ...
Nicole Stupka (13087914)
core  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Subchronic Exposure to Low-Dose Chlorfenapyr and Emamectin Benzoate Disrupts Kidney Metabolism in Rats

Toxics
Residues of the pesticides chlorfenapyr (CFP) and emamectin benzoate (EMB) often coexist in the environment and can be accumulated in the body. To understand the impact of these two chemicals on health, we investigated their effect on the kidneys.
Di Zhang, Xiao-Hua Song, Dan Yang, Mu-Zi Ge, Jun Qiu, Han-Qing Jiang, Yan-Yan Sun, Xiang-dong Li, Yi-Jun Wu   +8 more
doaj   +1 more source

Microhabitat Governs the Microbiota of the Pinewood Nematode and Its Vector Beetle: Implication for the Prevalence of Pine Wilt Disease

Microbiology Spectrum, 2022
Our understanding of environmental acquisition of microbes and migration-related alteration of microbiota across habitats has rapidly increased. However, in complex life cycles, such as for many parasites, exactly how these microbes are transmitted ...
Haokai Tian, Lilin Zhao, Tuuli-Marjaana Koski, Jianghua Sun   +3 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

A double-agent microRNA regulates viral cross-kingdom infection in animals and plants

The EMBO Journal
Plant arbovirus infection is regulated by a delicate interplay between virus, vector, and host. While microRNAs are known to be transmitted across species, their role as cross-kingdom effectors in influencing arbovirus infectious cycles remains poorly ...
Wan Zhao, Hong, Lu, Jiaming Zhu, Lan Luo, Feng Cui   +4 more
doaj   +1 more source

Calomys callosus: An Experimental Animal Model Applied to Parasitic Diseases Investigations of Public Health Concern

Pathogens, 2022
The appearance and spread of parasitic diseases around the world aroused the interest of the scientific community to discover new animal models for improving the quality and specificity of surveys. Calomys callosus is a rodent native to South America, an
Rafael Borges Rosa, Mylla Spirandelli da Costa, Samuel Cota Teixeira, Emilene Ferreira de Castro, Willyenne Marília Dantas, Eloisa Amália Vieira Ferro, Murilo Vieira da Silva   +6 more
doaj   +1 more source