Results 41 to 50 of about 2,726,823 (350)

Genetic variation in PTPN1 contributes to metabolic adaptation to high-altitude hypoxia in Tibetan migratory locusts

Nature Communications, 2018
Vertebrate adaptation to high-altitude life has been extensively investigated, while invertebrates are less well-studied. Here, the authors find signals of adaptive evolution in genomes of migratory locusts from the Tibetan Plateau, and implicate a PTPN1
Ding Ding, Guangjian Liu, Li Hou, Wanying Gui, Bing Chen, Le Kang   +5 more
doaj   +1 more source

Elevated Carbon Dioxide Levels Decreases Cucumber Mosaic Virus Accumulation in Correlation with Greater Accumulation of rgs-CaM, an Inhibitor of a Viral Suppressor of RNAi

Plants, 2020
Plant viruses cause a range of plant diseases symptoms that are often responsible for significant crop production losses and the severity and spread of the symptoms may be affected by climate change.
Huijuan Guo, Panpan Ge, Jiahui Tong, Yanjing Zhang, Xinhong Peng, Zihua Zhao, Feng Ge, Yucheng Sun   +7 more
doaj   +1 more source

Attractor neural networks storing multiple space representations: a model for hippocampal place fields

, 1998
A recurrent neural network model storing multiple spatial maps, or ``charts'', is analyzed. A network of this type has been suggested as a model for the origin of place cells in the hippocampus of rodents. The extremely diluted and fully connected limits
Battaglia, Francesco P., Treves, Alessandro   +1 more
core   +1 more source

Parental experiences orchestrate locust egg hatching synchrony by regulating nuclear export of precursor miRNA

Nature Communications
Parental experiences can affect the phenotypic plasticity of offspring. In locusts, the population density that adults experience regulates the number and hatching synchrony of their eggs, contributing to locust outbreaks.
Ya′nan Zhu, Jing He, Jiawen Wang, Wei Guo, Hongran Liu, Zhuoran Song, Le Kang   +6 more
doaj   +1 more source

Accumulation of DNA damage alters microRNA gene transcription in Arabidopsis thaliana

BMC Plant Biology, 2022
Background MicroRNAs (miRNAs) and other epigenetic modifications play fundamental roles in all eukaryotic biological processes. DNA damage repair is a key process for maintaining the genomic integrity of different organisms exposed to diverse stresses ...
Juan Du, Yang Liu, Lu Lu, Jianfei Shi, Longqian Xu, Qi Li, Xiaofei Cheng, Jinfeng Chen, Xiaoming Zhang   +8 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Genetic characterization of flea-derived Bartonella species from native animals in Australia suggests host-parasite co-evolution [PDF]

, 2011
Fleas are important arthropod vectors for a variety of diseases in veterinary and human medicine, and bacteria belonging to the genus Bartonella are among the organisms most commonly transmitted by these ectoparasites.
Adams, P.J., Bennett, M.D., Burmej, H., Fenwick, S.G., Irwin, P.J., Kaewmongkol, G., Kaewmongkol, S., McInnes, L.M., Ryan, U.   +8 more
core   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Novel rodent models for macular research [PDF]

, 2010
Background: Many disabling human retinal disorders involve the central retina, particularly the macula. However, the commonly used rodent models in research, mouse and rat, do not possess a macula.
Huber, Gesine, Heynen, Severin, Imsand, Coni, vom Hagen, Franziska, Muehlfriedel, Regine, Tanimoto, Naoyuki, Feng, Yuxi, Hammes, Hans-Peter, Grimm, Christian, Peichl, Leo, Seeliger, Mathias W., Beck, Susanne Christiane   +11 more
core   +1 more source

Assessment of spatial learning and memory in the Barnes maze task in rodents—methodological consideration

Naunyn-Schmiedeberg's Archives of Pharmacology, 2018
Among the methods valuable for assessing spatial learning and memory impairments in rodents, the Barnes maze (BM) task deserves special attention.
Kinga Gawel, Ewa Gibuła, M. Marszałek-Grabska, Joanna Filarowska, J. Kotlinska   +4 more
semanticscholar   +1 more source