Results 101 to 110 of about 566,311 (275)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Penerapan Metode Pembelajaran Role Playing dan Learning Community untuk Meningkatkan Keaktifan dan Prestasi Belajar Akuntansi Siswa Smk Negeri 1 Banyudono [PDF]

, 2013
The objectives of this research are to improve: (1) the activeness of the students in Grade XI of Accounting Expertise Program 1 of State Vocational High School 1 of Banyudono through the application of the learning model of the Role Playing and Learning
Febtiningtyas, W. A. (Wiyudha), Ivada, E. (Elvia), Siswandari, S. (Siswandari)   +2 more
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

THE EFFECT OF ROLE PLAYING METHOD TOWARD THE ABILITY OF FICTION READING COMPREHENSION OF HEARING IMPAIRMENT STUDENT

Jurnal Penelitian dan Pengembangan Pendidikan Luar Biasa, 2016
This research was carried out with the aim at describing: (1) the ability of fiction reading comprehension of student with hearing impairment of grade VIII at SMPLBN Malang before and after being applied role playing method, (2) the effect of role ...
Lestari Wahyuningtyas, Sinta Yuni Susilawati   +1 more
doaj   +2 more sources

PENERAPAN MODEL ROLE PLAYING UNTUK MENINGKATKAN KOMPETENSI KARAKTER SISWA MENGENAI PERISTIWA SEKITAR PROKLAMASI : Penelitian Tindakan Kelas di SDN 4 Cibodas Lembang Kelas V Semester 2 Tahun Ajaran 2013/2014 Kecamatan Lembang Kabupaten Bandung Barat [PDF]

, 2014
Penelitian tindakan kelas ini dilatarbelakangi oleh pentingnya kompetensi karakter. Kompetensi karakter dapat dibangun melalui proses interaksi siswa. Untuk itu diperlukan cara untuk meningkatkan dan mengembangkan kompetensi karakter.
Rusdiana, Engelina Rosy
core  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The Profession of Law: Columbia Law School’s Use of Experiential Learning Techniques to Teach Professional Responsibility [PDF]

, 1995
Columbia Law School\u27s ethics course, The Profession of Law, is an interactive, experiential exploration of legal ethics. The course puts students in a role and asks them to deal, with issues that most of them are likely to encounter, and then the ...
Liebman, Carol Bensinger
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source