Results 91 to 100 of about 6,987,443 (300)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Using Massively Multiplayer Role Playing Games (MMORPGs) to support Second Language Learning: A Case Study of the Student Journey

open access: yes, 2016
Massively Multiplayer Online Role Playing Games (MMORPGs) create large virtual communities. Online gaming shows potential not just for entertaining, but also in education.
Kongmee, Isara   +2 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Playing Against the Modern World? [Elektronisk resurs] : Role-Playing Games in Late Modernity

open access: yes, 2010
Playing Reality is an anthology of articles on live role-playing, a new art from where the Nordic countries are at the front edge. This book covers a wide range of topics and genres, from practical advice, historical reviews and visions of possible ...
Harding, Tobias,
core  

An Embodied Cognition Approach for Understanding Role-playing

open access: yes, 2012
The article proposes that the theories of grounded cognition and embodiment can be utilized in explaining the role-playing experience. Embodied cognition theories assume that cognition is not only a feature of the brain, but the body as a whole and it’s ...
Lankoski, Petri, Järvelä, Simo
core   +1 more source

Keefektifan Layanan Bimbingan Kelompok Melalui Teknik Role Playing untuk Mengurangi Perilaku Bulliying

open access: yesEdukasia, 2023
The existence of bullying behavior in schools is certainly a scourge for educational units. With this research, namely applying the role playing method to class VII students at TanjungBalai 4 Public Middle School for the 2023-2024 academic year, this ...
Stariah, Ahmad Syarqawi
doaj  

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

An Embodied Cognition Approach for Understanding Role-playing [Elektronisk resurs]

open access: yes, 2012
The article proposes that the theories of grounded cognition and embodiment can be utilized in explaining the role-playing experience. Embodied cognition theories assume that cognition is not only a feature of the brain, but the body as a whole and it’s ...
Lankoski, Petri,, Järvelä, Simo,
core  

Broadcast culture meets role-playing culture [PDF]

open access: yes, 2008
The production "Sanningen om Marika" is a rare example of a production that combines traditional broadcast culture with the participative culture fostered primarily within the larp community in the Nordic countries.
Denward, Marie, Waern, Annika
core  

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