Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
PENGARUH METODE BELAJAR ROLE PLAYING TERHADAP HASIL BELAJAR SISWA DI SMA KEMALA BHAYANGKARI KELAS XI IIS TAHUN AJARAN 2015-2016 [PDF]
, 2016 Penelitian ini bertujuan untuk mengetahui perbedaan hasil belajar siswa yang mendapatkan perlakuan metode konvensional dengan teknik diskusi dan metode pembelajaran bermain peran (role playing) pada mata pelajaran ekonomi.
ELIA JUNIAWATI, 125020074
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
EFEKTIVITAS ROLE PLAYING DALAM PENGEMBANGAN KOMPETENSI SOSIAL ANAK TK A BUNDA ASUH NANDA [PDF]
, 2016 Penelitian ini bertujuan untuk mengetahui efektivitas role playing dalam pengembangan kompetensi sosial. Subjek penelitian merupakan anak di TK A Bunda Asuh Nanda Kota Bandung.
Ratualep, Mayrinda
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Agent-Based Participatory Simulations: Merging Multi-Agent Systems and Role-Playing Games [PDF]
In 2001, Olivier Barreteau proposed to jointly use multi-agent systems and role-playing games for purposes of research, training and negotiation support in the field of renewable resource management.
Paul Guyot, Shinichi Honiden
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The Profession of Law: Columbia Law School’s Use of Experiential Learning Techniques to Teach Professional Responsibility [PDF]
, 1995 Columbia Law School\u27s ethics course, The Profession of Law, is an interactive, experiential exploration of legal ethics. The course puts students in a role and asks them to deal, with issues that most of them are likely to encounter, and then the ...
Liebman, Carol Bensinger
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
PENERAPAN MODEL ROLE PLAYING UNTUK MENINGKATKAN KOMPETENSI KARAKTER SISWA MENGENAI PERISTIWA SEKITAR PROKLAMASI : Penelitian Tindakan Kelas di SDN 4 Cibodas Lembang Kelas V Semester 2 Tahun Ajaran 2013/2014 Kecamatan Lembang Kabupaten Bandung Barat [PDF]
, 2014 Penelitian tindakan kelas ini dilatarbelakangi oleh pentingnya kompetensi karakter. Kompetensi karakter dapat dibangun melalui proses interaksi siswa. Untuk itu diperlukan cara untuk meningkatkan dan mengembangkan kompetensi karakter.
Rusdiana, Engelina Rosy
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source