Results 111 to 120 of about 566,311 (275)
Agent-Based Participatory Simulations: Merging Multi-Agent Systems and Role-Playing Games [PDF]
In 2001, Olivier Barreteau proposed to jointly use multi-agent systems and role-playing games for purposes of research, training and negotiation support in the field of renewable resource management.
Paul Guyot, Shinichi Honiden
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Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Predicting The Outcome of Marketing Negotiations: Role-Playing versus Unaided Opinions [PDF]
Role -playing and unaided opinions were used to forecast the outcome of three negotiations. Consistent with prior re search, role-playing yielded more accurate predictions.
JS Armstrong, Philip D. Hutcherson
core
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Wat-A-Game, a toolkit for building role-playing games about integrated water management [PDF]
, 2012 Participatory modeling and role-playing games have been successfully implemented for a few decades as tools for social learning and supporting water management and governance.
Abrami, Géraldine +8 more
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β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Role-Playing Game and Learning for Young People About Sustainable Development Stakes: An Experiment in Transferring and Adapting Interdisciplinary Scientific Knowledge [PDF]
The study refers to the interactions between socio-economic and natural dynamics in an island biosphere reserve by using companion modelling. This approach provides scientific results and involves interdisciplinarity. In the second phase of the study, we
Anne Rognant +3 more
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THE CORRELATION BETWEEN THE APPLICATION OF ROLE PLAYING AND STUDENTS’ ACHIEVEMENT IN SPEAKING FLUENCY AT THE SECOND GRADE OF MTsN BABAKAN CIREBON [PDF]
, 2012 SUSI MARYATI : THE CORRELATION BETWEEN THE APPLICATION OF ROLE PLAYING AND STUDENTS’ ACHIEVEMENT IN SPEAKING FLUENCY AT THE SECOND GRADE OF MTsN BABAKAN CIREBON. REG.NUMBER : 07430351 English is important and it used as international language.
SUSI MARYATI,
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Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source