Trait-Mediated Variation in Plant Interactive Roles Within Plant-Floral Visitor Networks. [PDF]
Plants (Basel)Baena-Díaz F +4 more
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Deciphering the Counterintuitive Role of Vascular Endothelial Growth Factor Signaling Pathways in Pulmonary Arterial Hypertension. [PDF]
Int J Mol SciScagliola R.
europepmc +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
The Relationship Between Watching Baseball Games at a Home Stadium and Team Identification With Subjective Well-Being Among Middle-Aged and Older Baseball Fans. [PDF]
J Aging ResNakahara J.
europepmc +1 more source
The Effectiveness of Peer Education, Mentorship and Role-Playing Approaches in Developing Clinical Skills Among Iranian Nursing Students: A Systematic Review. [PDF]
Health Sci RepGhonchehpour A +4 more
europepmc +1 more source
Retraction: Potassium bromate-induced nephrotoxicity and potential curative role of metformin loaded on gold nanoparticles. [PDF]
Sci Progeuropepmc +1 more source