Results 51 to 60 of about 5,466,183 (303)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

Role Stress sebagai Motivator Bagi Auditor: Analisis Teoritis Atas Dasar Teori-teori Motivasi

open access: yesJournal the Winners, 2008
The purpose of this paper explains the positive side of role stress which has long been regarded as the factor causing performance decrease and ultimately initiates job dissatisfaction.
Francisca Reni Retno Anggraini
doaj   +1 more source

Investigating the effect of role conflict and role ambiguity on employees' job stress :Articulating the role of work-family conflict [PDF]

open access: yesManagement Science Letters, 2013
Psychologists and researchers of management sciences are of great interest in subject of stress and the major reason for this is its impact on psychological well-being and organizational consequences.
Iraj Soltani   +3 more
doaj   +1 more source

MAPK-activated protein kinase 2-deficiency causes hyperacute tumor necrosis factor-induced inflammatory shock [PDF]

open access: yes, 2014
Background: MAPK-activated protein kinase 2 (MK2) plays a pivotal role in the cell response to (inflammatory) stress. Among others, MK2 is known to be involved in the regulation of cytokine mRNA metabolism and regulation of actin cytoskeleton dynamics ...
Brouckaert, Peter   +5 more
core   +1 more source

The Role of Metallothionein in Oxidative Stress [PDF]

open access: yesInternational Journal of Molecular Sciences, 2013
Free radicals are chemical particles containing one or more unpaired electrons, which may be part of the molecule. They cause the molecule to become highly reactive. The free radicals are also known to play a dual role in biological systems, as they can be either beneficial or harmful for living systems.
Branislav Ruttkay-Nedecky   +8 more
openaire   +3 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski   +9 more
wiley   +1 more source

The role of oxidative stress in gestational diabetes

open access: yesAnnales Academiae Medicae Silesiensis, 2023
Gestational diabetes mellitus (GDM) is one of the most common diseases that leads to complications during pregnancy. It has been noticed that GDM is accompanied by an increase in oxidative stress.
Kamila Stopińska, Adrianna Marzec
doaj   +1 more source

THE RELATIONSHIP BETWEEN A PATIENT\u27S STRESS LEVEL DURING HOSPITALIZATION AND HIS PERCEPTION OF HIS SIGNIFICANT FAMILY MEMBER\u27S ROLE IN PROVIDING SUPPORT [PDF]

open access: yes, 1981
A descriptive study was undertaken to investigate the relationship between a patient\u27s stress level during hospitalization and his perception of his significant family member\u27s role providing support. The following subproblems were also addressed: (
Johnson, Susan Carey Williams
core   +1 more source

Quantum Stress Tensor Fluctuations and their Physical Effects

open access: yes, 2007
We summarize several aspects of recent work on quantum stress tensor fluctuations and their role in driving fluctuations of the gravitational field. The role of correlations and anticorrelations is emphasized.
Abel Camacho   +4 more
core   +1 more source

Pediatric Oncology Nursing Competencies in Latin America and the Caribbean: A Scoping Review to Inform Practice, Education, and Research

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Nurses are central to cancer care for children and adolescents, yet no comprehensive synthesis has defined essential core competencies for pediatric oncology nursing (PON) practice internationally, particularly in Latin America and the Caribbean (LAC).
Luís Carlos Lopes‐Júnior   +7 more
wiley   +1 more source

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