Results 71 to 80 of about 6,570,416 (336)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Integrating AI in higher education: transforming teachers' roles in boosting student agency

open access: yesEducational Technology Quarterly
Artificial intelligence (AI) has emerged as an integral part of education. It is revolutionising teaching and learning by offering personalised and engaging atmospheres to learners.
Devi Prasad Adhikari   +1 more
doaj   +1 more source

Understanding Indonesia's role in the ‘ASEAN Outlook on the Indo‐Pacific’: A role theory approach

open access: yesAsia & the Pacific Policy Studies, 2020
Following other regional powers, Indonesia announced its own interpretation of the Indo‐Pacific concept in 2018. Considering Indonesia's strategic position in the Indo‐Pacific, does this announcement indicate the prospects of a more active Indonesian ...
I Gusti Bagus Dharma Agastia
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

The European Union’s role in a changing International Order: The Global Gateway Initiative [PDF]

open access: yesPopulação e Sociedade
The power structures and norms of the Liberal International Order (LIO) are changing due to the rise of powers with reformist and revisionist agendas.
Flávio Bastos da Silva
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Foreign Policy Analysis

open access: yesCzech Journal of International Relations, 2019
Role theory, which is based on the symbolic interactionism of George H. Mead, is increasingly used in foreign policy analysis. The goal of this paper is twofold.
Vít Beneš
doaj   +1 more source

Three roles of ideal theory

open access: yesEthics, Politics & Society, 2023
Rawlsian ideal theory is meant to perform various roles in non-ideal theory. In this paper, I distinguish between three roles, and I consider the extent to which we can expect ideal theory to perform them. It is meant to serve as a target to guide non-ideal theorising in the long-term.
openaire   +2 more sources

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

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