Results 131 to 140 of about 3,138,985 (315)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Shifting Sands: Changing gender roles among refugees in Lebanon [PDF]
, 2013 The conflict in Syria has created a humanitarian crisis, with almost two million people having fled to neighbouring countries in the hope of escaping the violence.
El-Masri, Roula +2 more
core
intervención del trabajador social en formación desde el enfoque praxeológico
Perspectivas, 2018 En este artículo queremos mostrar que la intervención del trabajador social realizada desde un ejercicio praxeológico –y como resultado de una investigación disciplinar– se caracteriza por los roles asumidos por los estudiantes y por la articulación de ...
María Otilia Pulecio Bazurto +1 more
doaj
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Valued social roles for people with learning disabilities [PDF]
, 2013 Social identity theory maintains that individuals define themselves according to their social groups, which in turn impacts self-esteem. Valued social roles are assumed to influence identity and self-concept.
Taylor, E.
core
La dinámica relacional del transporte como sistema complejo
Perspectivas, 2018 El siguiente estudio se centra en el análisis del transporte como sistema complejo desde la mirada de la dinámica relacional, orientándose a la comprensión de los aspectos externos e internos en relación a la situación.
José Miguel Mayorga González
doaj
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source