Results 121 to 130 of about 3,138,985 (315)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Caught in the Middle? Occupancy in Multiple Roles and Help to Parents in a National Probability Sample of Canadian Adults [PDF]
This paper considers for a Canadian national probability sample of middle-aged women and men the question of how typical is the experience of being "caught in the middle" between being the adult child of elderly parents and other roles.
Carolyn J. Rosenthal +2 more
core
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Managers or Librarians: Roles and Competencies in RDM [PDF]
, 2018 Presentation for the 2018 International Conference on Knowledge Management. This presentation describes a workshop to analyze the roles and competencies of data curators in different contexts such as enterprises and academic libraries in mainland ...
Fan, Zhenjia
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Women?s health in mid-life: life course social roles and agencyas quality [PDF]
, 2006 Data from a prospective British birth cohort study showed that women who were childless, lone mothers or full-timehomemakers between the ages of 26 and 54 were more likely to report poor health at age 54 than women who occupiedmultiple roles between ...
Bartley, M, McMunn, A, Kuh, D
core
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
The changing roles and identities of library and information services staff [PDF]
, 2010 A review of the changing roles of library, IT and e-learning staff from 1960 to date.
Law, Derek
core
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
AMA Journal of Ethics, 2002 Role-modeling of more senior physicians by junior physicians perpetuates outdated paradigms in medicine, and the patient-centered care urged by society today would be better accomplished through mentoring. Virtual Mentor is a monthly bioethics journal published by the American Medical Association.
openaire +2 more sources