Results 71 to 80 of about 2,406,276 (362)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Cold homes are associated with poor biomarkers and less blood pressure check-up: English Longitudinal Study of Ageing, 2012–2013 [PDF]
, 2016 It has been known that outdoor temperature influences seasonal fluctuation of blood pressure and cholesterol levels, but the role of indoor temperature has been less studied. Therefore, the aim of the present study was to examine the associations between
Shiue, Ivy, Ivy Shiue
core +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Toward Polymeric Room Temperature Acid Generators
ChemistryOpenAlthough a variety of acid‐generating molecules have been developed, the formation of toxic byproducts and the need for light‐activation or temperatures that may be incompatible with physiological conditions leave room for the optimization of ...
Joel W. Roberts +6 more
doaj +1 more source
Artificial two-dimensional polar metal at room temperature
Nature Communications, 2018 Materials that combine metallic behaviour with stable electric polarization are scarce despite being proposed in the 1960s. Here the authors engineer a perovskite heterostructure where 2D polar metallic behavior coexists with built-in electric ...
Yanwei Cao +18 more
doaj +1 more source
Room temperature electrically pumped topological insulator lasers
Nature Communications, 2021 Topological insulator lasers offer robustness and efficiency due to their unique properties but usually require cryogenic temperatures or optical pumping.
Jae-Hyuck Choi +6 more
doaj +1 more source
, 2010 The electrical resistivity and the anisotropic magnetoresistance (AMR) was investigated for Ni Co alloys at and below room temperature. The Ni Co alloy layers having a thickness of about 2 micron were prepared by electrodeposition on Si wafers with ...
Pádár, József +9 more
core +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
IoT-Enabled Temperature Controlled Room for Patients
Journal of Engineering Technology and Applied PhysicsThe physical environment in healthcare settings is considered important for patient comfort and recovery. Among other environmental factors, room temperature is recognized as a crucial environmental factor that can significantly affect the patient’s ...
Ahmad Mustaqim Ishak +4 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source