Results 41 to 50 of about 86,471 (315)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Development and Characterization of Poly(1-vinylpyrrolidone-co-vinyl acetate) Copolymer Based Polymer Electrolytes

The Scientific World Journal, 2014
Gel polymer electrolytes (GPEs) are developed using poly(1-vinylpyrrolidone-co-vinyl acetate) [P(VP-co-VAc)] as the host polymer, lithium bis(trifluoromethane) sulfonimide [LiTFSI] as the lithium salt and ionic liquid, and 1-ethyl-3-methylimidazolium bis(
Nurul Nadiah Sa’adun, Ramesh Subramaniam, Ramesh Kasi   +2 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Low Toxic Ionic Liquids, Liquid Catanionics, and Ionic Liquid Microemulsions

, 2011
In the future the demand of sustainable and low toxic surfactants and solvents will constantly increase. In this article, we present some new approaches to meet these requirements.
Dengler, S., Didier Touraud, Harrar, Agnes, Harrar, A., Dengler, Susanne, Klein, R., Rengstl, Doris, Eva Maurer, Werner Kunz, Oliver Zech, Susanne Dengler, Agnes Harrar, Maurer, E., Kunz, Werner, Kunz, W., Touraud, Didier, Doris Rengstl, Regina Klein, Klein, Regina, Maurer, Eva, Rengstl, D., Touraud, D., Zech, O.   +22 more
core   +1 more source

Temperature-dependent thermal expansivities of silicate melts: The system anorthite-diopside [PDF]

, 1992
The temperature-dependent thermal expansivities of melts along the join anorthite-diopside have been determined on glassy and liquid samples using a combination of calorimetry, dilatometry, and Pt double bob Archimedean densitometry.
Knoche, Ruth, Dingwell, Donald B., Webb, Sharon L.   +2 more
core   +1 more source

DFT-based investigation of solvation of Nd(III)/Yb(III) cations in room-temperature ionic-liquid

, 2023
We report a DFT study on the solvation of bare rare-earth (RE) cations [Nd(III) and Yb(III)] in the room-temperature ionic-liquid (RTIL) based on 1,3-dimethyl-imidazolium+, PF6-, [MMI][PF6].
Theresa L., Windus, Tamalika, Ash
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Electrodeposition and Behavior of Palladium in a Room-temperature Ionic Liquid

International Journal of Electrochemical Science, 2017
This paper reports the electrodeposition of Pd in the room-temperature ionic liquid 1-ethyl-3-methylimidazolium trifluoroacetate ([emim]TA). The electrochemical behavior of PdCl2 in [emim]TA was investigated using cyclic voltammetry. Cyclic voltammograms
Xiaoli Xi, Shanshan Song, Zuoren Nie, Liwen Ma   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Palladium Nanoparticles Synthesized by Pulsed Electrolysis in Room-Temperature Ionic Liquid

International Journal of Electrochemical Science, 2016
Synthesis of palladium nanoparticles by pulsed electrolysis was investigated in the room-temperature ionic liquid 1-butyl-3-methylimidazolium chloride ([C4mim]Cl) using palladium chloride (PdCl2) as the palladium source.
Gwangwon Park, Jesik Park, YoungjuCho, Churl KyoungLee   +3 more
doaj   +1 more source