Results 191 to 200 of about 295,445 (314)

Contrasting associations of blood lipids with risk of myocardial infarction in Chinese and European adults. [PDF]

Eur Heart J Open
Wang H, Clarke R, Kartsonaki C, Millwood I, Walters R, Hill M, Avery D, Yu C, Sun DY, Lv J, Li S, Li L, Chen Z, Wright N, Bennett DA.   +14 more
europepmc   +1 more source

Immune Predictors of Radiotherapy Outcomes in Cervical Cancer

Advanced Science, EarlyView.
This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang, Jie Zhu, Zequn Ding, Zhiyuan Xie, Xingchen Liu, Feihong Zhang, Xiaojun Liu, Yan Zhang, Haiyan Chen   +8 more
wiley   +1 more source

Parkinsonism in Gerstmann-Sträussler-Scheinker disease: A case report. [PDF]

eNeurologicalSci
Poveda S, Montealegre-Claros JS, Lancheros LM, Cruz MA, Pacheco OB.   +4 more
europepmc   +1 more source

Biodegradable Carbonate Nanogels Loaded with Anti MFAP‐5 siRNA for Anti‐stromal Therapy of Hepatocellular Carcinoma

Advanced Science, EarlyView.
Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider, Alexander Fuchs, Michael Fichter, Vanessa Bolduan, Jenny Schunke, Özlem Akilli, Nádia C. Correia, Yannick Ehlers, Christian Czysch, Pia Winterwerber, Eliana Stanganello, Barbara Schrörs, Mustafa Diken, Christoph Eckert, Shusruto Rishik, Andreas Keller, Jörn M. Schattenberg, Stephan Grabbe, Matthias Bros, Lutz Nuhn, Leonard Kaps   +20 more
wiley   +1 more source

Corrigendum to "Exopolysaccharide from the yeast Papiliotrema terrestris PT22AV for skin wound healing" [J. Adv. Res. 46 (2023) 61-74]. [PDF]

J Adv Res
Hamidi M, Okoro OV, Ianiri G, Jafari H, Rashidi K, Ghasemi S, Castoria R, Palmieri D, Delattre C, Pierre G, Mirzaei M, Nie L, Samadian H, Shavandi A.   +13 more
europepmc   +1 more source

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source

Author's Reply: Critical Limitations in Systematic Reviews of Large Language Models in Health Care.

J Med Internet Res
Python A, Li H, Fu JF.
europepmc   +1 more source

Tooth Loss, Nutrition, and Oral Health-Related Quality of Life in Older Adults: Evidence from a Structural Equation Model. [PDF]

Int J Environ Res Public Health
Della Terra Mouco Garrido B, Pereira PSS, Foloni K, Pegoraro HD, Souza IR, Bastos JRM, Foratori-Júnior GA, Yamauti M, Ferreira RC, Bastos RS.   +9 more
europepmc   +1 more source

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, EarlyView.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

Wastewater surveillance in the military: how deployed members of the armed forces can monitor outbreaks on military vessels. [PDF]

Front Epidemiol
Gitter A, Mena KD, Crum M, Butler E.
europepmc   +1 more source