Results 61 to 70 of about 147,577 (344)

Push-out bond strength of different endodontic obturation material at three different sites : in-vitro study [PDF]

, 2017
The key to success of any root canal therapy is adequate obturation of the prepared root canal space. Root canal sealers are not dimensionally stable and might dissolve partially over a period of time.
Gupta, Manas, Mishra, Pankaj, Mishra, Sunil S., Sharma, Anjna   +3 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

A case of maxillary second premolar with 3 teeth and 4 root canals and a literature review

口腔疾病防治, 2019
Objective To explore the discovery and treatment of multiple root canals in the maxillary second pre⁃ molar to provide a reference for root canal therapy.
LI Hong, XIN Bingchang, TENG Qi
doaj   +1 more source

Root canal treatment of maxillary second molar with three mesial buccal root canals: a case report and literature review

口腔疾病防治, 2021
Objective To explore the key points of clinical diagnosis and treatment of three mesiobuccal root canals. Methods In the procedure of endodontic therapy for the upper left second molar with pulpitis, through root canal exploration under a dental ...
MEI Xiaohan, LIU Jin, HONG Tao, YOU Suxia, CHENG Xiaogang, TIAN Yu   +5 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Endodontic therapy and Medication-related osteonecrosis of the jaw onset: a scoping review and expert opinion-based qualitative meta-synthesis

BMC Oral Health
Introduction Medication-related osteonecrosis of the Jaw (MRONJ) is a serious side effect of bone-modifying agents (BMAs), including bisphosphonates, denosumab, and antiangiogenic drugs.
R. Mauceri, M. Coppini, V. C. A. Caponio, F. Zamparini, C. Prati, G. Campisi   +5 more
doaj   +1 more source

Anatomical Evaluation of Root Apex Morphology in Frontal Maxillary Teeth [PDF]

, 2015
The success of root canal therapy is dependent on the clinician’s knowledge of root canal morphology with goal to precisely locate all canals, properly clean, shape and obturate the canal space.
Dimova, Cena, Kovacevska, Ivona, Papakoca, Kiro, Zlatanovska, Katerina   +3 more
core  

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Procedure refinement, easy operation--root canal treatment progress

口腔疾病防治, 2016
Over the past ten years, with the progress of science and technology and improvement of equipment, the root canal treatment level has been promoted rapidly, and the root canal treatment effect has realized qualitative improvement.
FAN Ming-wen
doaj   +1 more source

Mechanical activation with Easy Clean device enhanced organic tissue removal from simulated internal root resorption in a laboratory evaluation

BMC Oral Health, 2023
Background Considering the irregular shape of the root canal, removing inflamed pulp and granulation tissue completely from internal resorption cavities during chemomechanical preparation can be challenging. This study aimed to evaluate the effectiveness
Laise Pena Braga Monteiro, Sérgio Emilio Miranda de Sousa, Roberta Fonseca de Castro, Emmanuel João Nogueira Leal da Silva, Juliana Melo da Silva Brandão   +4 more
doaj   +1 more source