Results 31 to 40 of about 4,749 (216)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Effects of Procedural Errors on Root Canal Treatment Outcomes: A Retrospective Cohort Study of Cases Treated by Sixth-year Dental Students

European Endodontic Journal
Objective: This study assessed the effects of various types of procedural errors arising from root canal instru-mentation on initial root canal treatment outcomes.
Sirashat Teerawanitsan, Kanet Chotvorrarak, Titalee Jirathanyanatt   +2 more
doaj   +1 more source

Clinical case: second mandibular premolar with three root canals

Эндодонтия Today, 2021
Successful and predictable endodontic treatment requires knowledge of root canal anatomy and morphology variations. In cases where X-ray images do not help to clarify the anatomy of the root canals, it is recommended to use magnifying devices. The second
E. V. Vusataya, R. G. Pomogalov
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Procedure refinement, easy operation--root canal treatment progress

口腔疾病防治, 2016
Over the past ten years, with the progress of science and technology and improvement of equipment, the root canal treatment level has been promoted rapidly, and the root canal treatment effect has realized qualitative improvement.
FAN Ming-wen
doaj   +1 more source

Latest concepts in root canal treatment [PDF]

British Dental Journal, 2005
This paper highlights one aspect of a presentation to be given at the BDA Conference and is written in the context of dentistry in primary care. Careful oral health assessment as a foundation to good treatment planning and quality dentistry is not new, but there are a number of important new perspectives emerging across countries and healthcare systems
openaire   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Identification and clinical management of extra root in mandibular first molars: A series of case reports

Journal of Oral Research and Review, 2018
The radix entomolaris/paramolaris is the major anatomical variant in mandibular first molars. If present, an awareness and understanding of this unusual root and its root canal morphology can contribute to the successful outcome of root canal treatment ...
Ashish Jain, Raji Viola Solomon, P Karunakar, M S Ranga Reddy   +3 more
doaj   +1 more source

Diagnosis and root canal treatment of a mandibular second premolar with three root canals

International Endodontic Journal, 2003
AbstractAim  To present a case of a mandibular second premolar with three root canals.Summary  An accurate diagnosis of the morphology of the root canal system is a prerequisite for successful root canal treatment. A review of the literature reveals a low incidence of all types of premolars with three root canals.
Rodig, T., Hülsmann, Michael
openaire   +3 more sources