Results 41 to 50 of about 171,329 (359)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Latest concepts in root canal treatment [PDF]

open access: yesBritish Dental Journal, 2005
This paper highlights one aspect of a presentation to be given at the BDA Conference and is written in the context of dentistry in primary care. Careful oral health assessment as a foundation to good treatment planning and quality dentistry is not new, but there are a number of important new perspectives emerging across countries and healthcare systems
openaire   +2 more sources

Quality of Root Canal Obturation Performed by Senior Undergraduate Dental Students [PDF]

open access: yes, 2015
The aim of the present study was to assess the quality of canal obturation performed by undergraduate denal students at Saveetha Dental College and Hospitals, Chennai.
Nagaraja, S. (Sundahnath)
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Identification and clinical management of extra root in mandibular first molars: A series of case reports

open access: yesJournal of Oral Research and Review, 2018
The radix entomolaris/paramolaris is the major anatomical variant in mandibular first molars. If present, an awareness and understanding of this unusual root and its root canal morphology can contribute to the successful outcome of root canal treatment ...
Ashish Jain   +3 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Pain associated with root canal treatment

open access: yesInternational Endodontic Journal, 2009
AbstractAim  To determine the pain experienced by patients during root canal treatment and to correlate with age and gender, pulpal diagnosis, previous periapical status, dental characteristics and length of treatment.Methodology  One hundred and seventy‐six patients (68 men and 108 women), with ages ranged from 6 to 83 years, were randomly recruited ...
Segura-Egea, Juan José   +3 more
openaire   +4 more sources

Green discoloration of the crown after internal root resorption treatment with grey mineral trioxide aggregate (MTA) [PDF]

open access: yes, 2011
Root resorption (RR) is the loss of dental hard tissues as a result of clastic activities. Internal inflammatory root resorption (IRR) is a type of RR characterized by progressive loss of tooth substance starting from the root canal wall.
Alonso Ezpeleta, Luis Oscar   +4 more
core   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

open access: yesMolecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad   +35 more
wiley   +1 more source

The use of Bioceramics as root-end filling materials in periradicular surgery: a literature review [PDF]

open access: yes, 2018
Introduction: Periradicular surgery involves the placement of a root-end filling following root-end resection, to provide an apical seal to the root canal system. Historically several materials have been used in order to achieve this seal.
Abusrewil, Sumaya M.   +2 more
core   +1 more source

Home - About - Disclaimer - Privacy