Results 71 to 80 of about 407,625 (291)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The Method of Root Cause Analysis and Solutions (MRCAS) [PDF]

open access: yes, 2008
Most of discourses in meetings, discussions, conferences and talk shows are not equipped with a method which analyzes the root cause and its fundamental solution, and even without the need of analyzing it. As the result,.
P, A. H. (Ari)   +2 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Bundled interventions for consumption management and monitoring of personal protective equipment in COVID-19 pandemic in Hong Kong local hospitals

open access: yesBMJ Open Quality, 2020
Since the outbreak of COVID-19 in December 2019, there had been global shortage of personal protective equipment (PPE) supply due to the breakage of supply chain and also the forbidding of PPE exported by various countries.
Wai-Man Kwan   +9 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Improving safety through root cause analysis [PDF]

open access: yes, 1991
Operations at the US Department of Energy -- Savannah River Site (SRS) include such diverse facilities as reactors, fuel fabrication, chemical processing, coal burning power houses, analytical laboratories and research facilities.
Taylor, K., Gatlin, J. L.
core  

Cause-effect analysis diagram.

open access: yes, 2023
Systematically analysing the relative importance and hierarchical relationships among the influencing factors of the cross-border e-commerce ecosystem holds rich theoretical value and practical significance for the development of this ecosystem.
Brian Sheng-Xian Teo (16814603)   +2 more
core   +1 more source

Psychiatric outpatients flow and waiting time improvement using PDSA and RCA techniques

open access: yesPayesh, 2016
Objective (s): Waits and delays are symptoms of disrupted patient flow that has a negative effect on patient satisfaction, staff retention and referrals.
Seyedeh Hamideh Ghazimirsaeid   +1 more
doaj  

Investigation of a CubeSat in Orbit Anomaly through Verification on Ground

open access: yesAerospace, 2020
Given the role of Cubesats in the new space economy, a statistically relevant number of CubeSats have flown, and considering the high percentage of failed missions, the investigation of in-orbit anomalies becomes of paramount importance.
Fabrizio Stesina, Sabrina Corpino
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

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