Results 151 to 160 of about 7,285,916 (251)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
On, on, on, the boys came marching, like a grand majestic sea [first line of chorus]
strophic with choruspiano and voiceads on inside front and on back covers for Root & Cady stock458-3Johns Hopkins University, Levy Sheet Music Collection, Box 089, Item 080Words and Music by Geo. F.
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Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Open box of Root Boy Slim "Root" eyeglasses, Warner Theatre, Washington, D.C., March 7, 1978
, 1978 Paper eyeglasses in the shape of the word "Root" to be given out to audience members during Root Boy Slim's performance at the Warner Theatre in Washington, D.C., March 7, 1978. This concert was a going-away celebration for WFHS DJ Josh Brooks.
Hamerman, Don
core
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Singing, swinging, singing sweetly a joyful strain [first line of chorus]
, 1873 strophic with choruspiano and voiceads on inside front and on back covers for Geo. F. Root stock19Johns Hopkins University, Levy Sheet Music Collection, Box 135, Item 013By Frank Howard.
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Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source