Results 131 to 140 of about 1,302,245 (288)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Path to Achieving Higher Productivity in Popcorn Under Drought Conditions

Agronomy
This study investigated alternative pathways involving adaptive traits associated with drought tolerance in popcorn cultivated under soil water restriction through path analysis.
Jhean Torres Leite, Antônio Teixeira do Amaral Junior, Valter Jário de Lima, Divino Rosa dos Santos Junior, Uéliton Alves de Oliveira, Flávia Nicácio Viana, Monique de Souza Santos, Letícia Peixoto Gomes, Danielle Leal Lamêgo, Carolina Macedo Carvalho, Wallace de Paula Bernado, Eliemar Campostrini, Henrique Duarte Vieira, Samuel Henrique Kamphorst   +13 more
doaj   +1 more source

Endodermal suberin restricts root leakage of cesium: a suitable tracer for potassium

Physiologia Plantarum
AbstractAn urgent challenge within crop production is to maintain productivity in a world plagued by climate change and its associated plant stresses, such as heat, drought and salinity. A key factor in this endeavor is to understand the dynamics of root suberization, and its role in plant‐water relations and nutrient transport.
Morten Winther Vestenaa, Søren Husted, Francesco Minutello, Daniel Pergament Persson   +3 more
openaire   +4 more sources

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Effect of Root Restriction on the Growth, Photosynthesis Rate, and Source and Sink Relationship of Chilli (Capsicum annuum L.) Grown in Soilless Culture. [PDF]

Biomed Res Int, 2020
Zakaria NI, Ismail MR, Awang Y, Megat Wahab PE, Berahim Z.   +4 more
europepmc   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Small RNA Sequencing Analysis of miRNA Expression Reveals Novel Insihts into Root Formation under Root Restriction Cultivation in Grapevine (Vitis vinifera L.). [PDF]

Int J Mol Sci, 2020
Li H, Gao Z, Zahid MS, Li D, Javed HU, Wang L, Song S, Zhao L, Xu W, Zhang C, Ma C, Wang S.   +11 more
europepmc   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source