Results 91 to 100 of about 302,461 (263)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Biocompatibility of root-end filling materials: recent update
Restorative Dentistry & Endodontics, 2013 The purpose of a root-end filling is to establish a seal between the root canal space and the periradicular tissues. As root-end filling materials come into contact with periradicular tissues, knowledge of the tissue response is crucial.
Payal Saxena +2 more
doaj +1 more source
Effects of warming and parasitism on root traits and the root economics space
Functional EcologyAbstract Plants infected by parasitic species might be further stressed by climate warming as both factors can influence the host plant's nutrient acquisition and growth. The root economics space, defined by root functional traits, reflects a plant's nutrient acquisition strategy.
Yongge Yuan, Mark van Kleunen, Junmin Li
openaire +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
PlantsSoil nutrients and water are often distributed heterogeneously in space, yet how plant roots forage in response to such heterogeneity and how their strategies relate to functional traits remain poorly understood.
Liuduan Wei +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Brazilian Oral ResearchRevascularization of immature teeth with necrotic pulps traditionally involves the use of triple antibiotic paste, which may sometimes lead to undesirable complications.
Claudia Medianeira Londero PAGLIARIN +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Composition Operators on the Little Lipschitz Space of a Rooted Tree
Mediterranean Journal of MathematicsIn this work, we study the composition operators on the little Lipschitz space ${\mathcal L}_0$ of a rooted tree $T$, defined as the subspace of the Lipschitz space ${\mathcal L}$ consisting of the complex-valued functions $f$ on $T$ such that $$\lim_{|v|\to\infty}|f(v)-f(v^-)|=0,$$ where $v^-$ is the vertex adjacent to the vertex $v$ in the path from ...
Colonna, Flavia +1 more
openaire +2 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source