Results 91 to 100 of about 509,537 (315)

Metabolic profile, antimicrobial and toxicity evaluation of Azadirachta indica roots

open access: green, 2022
Ana Lúcia Eufrázio Romão   +4 more
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

The Dark Shadows: Unraveling the Impact of Supervisor Bottom Line Mentality on Workplace Jealousy Through Job Insecurity and Resilience

open access: yesSAGE Open
Supervisor BLM is referred to as a unidimensional frame of mind that revolves around the attainment of bottom-line outcomes; this mentality is commonly found in today’s organizations.
Sehrish Munaf, Amir Gulzar, Hina Fayyaz
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Variation in Root-Associated Microbial Communities among Three Different Plant Species in Natural Desert Ecosystem

open access: yesPlants
The process and function that underlie the assembly of root-associated microbiomes may be strongly linked to the survival strategy of plants. However, the assembly and functional changes of root-associated microbial communities in different desert plants
Yulin Zhang   +4 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

When do people want to retire? The preferred retirement age gap between Eastern and Western Europe explained

open access: yesStudies of Transition States and Societies, 2016
Debates surrounding working longer focus mainly on increasing legal and effective retirement ages, leaving the preferred retirement age largely overlooked.
Wouter de Tavernier, Ave Roots
doaj  

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