The receptor tyrosine kinase Ror is required for dendrite regeneration in Drosophila neurons.
PLoS Biology, 2020 While many regulators of axon regeneration have been identified, very little is known about mechanisms that allow dendrites to regenerate after injury.
Derek M R Nye +8 more
doaj +4 more sources
Vitamins A and D Enhance the Expression of Ror-γ-Targeting miRNAs in a Mouse Model of Multiple Sclerosis [PDF]
Molecular Neurobiology, 2021 Abstract Background: Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system. Autoreactive T cells including cells with a Th17 phenotype are critical players in MS pathogenesis. In this study, we investigated the effects of VitA/D on miRNAs expression involved in Th17 development neuroinflammation using (EAE).
Marziyeh Mohammadi kordkhayli +6 more
openaire +3 more sources
ROR Inverse Agonist Suppresses Insulitis and Prevents Hyperglycemia in a Mouse Model of Type 1 Diabetes [PDF]
Endocrinology, 2015 Hyperglycemia associated with type 1 diabetes is a consequence of immune-mediated destruction of insulin producing pancreatic β-cells. Although it is apparent that both CD8(+) T cells and TH1 cells are key contributors to type 1 diabetes, the function of TH17 cells in disease onset and progression remains unclear.
Laura A, Solt +4 more
semanticscholar +6 more sources
IFN-γ-Primed hUCMSCs Significantly Reduced Inflammation via the Foxp3/ROR-γt/STAT3 Signaling Pathway in an Animal Model of Multiple Sclerosis [PDF]
Frontiers in Immunology, 2022 Our previous study showed that interferon gamma (IFN-γ) might enhance the immunosuppressive properties of mesenchymal stem cells (MSCs) by upregulating the expression of indoleamine 2,3-dioxygenease. Therefore, we treated experimental autoimmune encephalomyelitis (EAE) mice, an animal model of multiple sclerosis (MS), with IFN-γ-primed human umbilical ...
Xiao Ling +11 more
openaire +4 more sources
Differential Expression Pattern of linc-ROR Spliced Variants in Pluripotent and Non-Pluripotent Cell Lines [PDF]
Cell Journal, 2022 Objective: The human large intergenic non-coding RNA-regulator of reprogramming program (linc-ROR) is known as astem cell specific linc-RNA. linc-ROR counteracts differentiation via sequestering microRNA-145 (miR-145) that targets OCT4 transcript ...
Fatemeh Mirzadeh Azad +8 more
doaj +2 more sources
A Model for Sorting Activities to Be Outsourced in Civil Construction Based on ROR-UTADIS [PDF]
Mathematical Problems in Engineering, 2016 The subcontractor’s selection problem is currently treated as a supply chain problem with a prequalification procedure to balance the main objectives of the client: cost, quality, and time. Unfortunately, most of the selection processes are analysed under the same methodology without considering that variations in project, type of activity, and other ...
Rachel Perez Palha +2 more
openaire +2 more sources
The orphan nuclear receptor RORα and group 3 innate lymphoid cells drive fibrosis in a mouse model of Crohn’s disease [PDF]
Science Immunology, 2016 RORα contributes to the profibrotic response in the gut in a mouse model of infection-induced gut inflammation.
Bernard C, Lo +7 more
openaire +4 more sources
Adverse events associated with statin co-use in breast cancer patients: a disproportionality analysis based on the FDA Adverse Event Reporting System [PDF]
Therapeutic Advances in Drug SafetyBackground: An increasing number of breast cancer patients are using statins concomitantly. However, there are relatively few safety studies on the association between statins and adverse events (AEs) during breast cancer treatment. Objective: This study
Yunnan Zhang +5 more
doaj +2 more sources
Cancer Management and Research, 2021 Yanjun Mi,1,* Yongwen Li,2,* Zhuo He,3,* Donghan Chen,2 Qingqi Hong,2 Jun You2 1Department of Medical Oncology, The First Affiliated Hospital of Xiamen University, Teaching Hospital of Fujian Medical University, Xiamen, Fujian Province, 361003, People ...
Mi Y, Li Y, He Z, Chen D, Hong Q, You J
doaj +2 more sources
Age Group and Gender Estimation in the Wild With Deep RoR Architecture [PDF]
IEEE Access, 2017 Automatically predicting age group and gender from face images acquired in unconstrained conditions is an important and challenging task in many real-world applications.
Ke Zhang +7 more
doaj +2 more sources