Results 111 to 120 of about 22,830 (226)

GTx-186 inhibits growth of ROS1-dependent cell lines.

, 2013
A. GTx-186 inhibits the growth of HCC78 lung carcinoma cells. HCC78 lung carcinoma cells were plated in growth medium and treated with indicated concentrations of GTx-186 or crizotinib on days 1 and 6.
Muralimohan Yepuru (502013), Juhyun Kim (502019), Michael L. Mohler (502018), Yun Wang (32846), Nelson Levy (502022), Duane D. Miller (238777), Ramesh Narayanan (238761), Christopher C. Coss (502014), Linda M. Snyder (502020), James T. Dalton (238784), Christina M. Barrett (502017), Zhongzhi Wu (502015), Yali He (502021), Matthew N. Bauler (502016)   +13 more
core   +1 more source

Characterization of Ros1 cDNA from a Human Glioblastoma Cell Line [PDF]

, 1990
We have isolated and characterized a human ROS1 cDNA from the glioblastoma cell line SW-1088. The cDNA, 8.3 kilobases long, has the potential to encode a transmembrane tyrosine-specific protein kinase with a predicted molecular mass of 259 kDa.
Wigler, M. H., O'Neill, K., Riggs, M., Birchmeier, C.   +3 more
core   +1 more source

11‐year‐old girl presenting with blurred vision and progressive right arm weakness

Brain Pathology, Volume 36, Issue 6, November 2026.
Trung Toan Tran, Thi My Hanh Luong, Bérengère Dadone‐Montaudié, Hong Nhung Ta, Thai Hoc Nguyen, Fanny Burel‐Vandenbos, Gia Du Pham   +6 more
wiley   +1 more source

Identification of FIG-ROS1 fusion in tumor ID 749 from Analysis of Receptor Tyrosine Kinase ROS1-Positive Tumors in Non–Small Cell Lung Cancer: Identification of a FIG-ROS1 Fusion

, 2012
(A) Schematic representation of the genomic region containing fig and ros1. Probes set 1 derived from ros1 (orange) and the deleted region (green). Probe set 2 derived from ros1 (orange) and fig (green).
Yerong Hu (233501), Herbert Haack (233511), Jennifer S. Mack (14988033), Daiqiang Li (14977056), Matthew R. Silver (14988036), Katherine E. Crosby (14988027), Meghan E. Kelly (14988030), Ting-Lei Gu (5649880), Xinmin Zhou (137494), Victoria M. Rimkunas (14988024)   +9 more
core   +1 more source

A study detection of the ROS1 gene fusion by FISH and ROS1 protein expression by IHC methods in patients with ovarian malignant or borderline serous tumors

, 2018
Objective: ROS1 is an orphan receptor protein tyrosine kinase which is supposed to undergo genetic rearrangement in carcinogenesis. In the current study, we aimed to investigate the frequency and clinicopathologic features associated with ROS1 gene ...
ŞİMŞEK, TAYUP, Pestereli, Elif, ERDOĞAN, GÜLGÜN, BAYRAMOĞLU, ZEYNEP, ÖZCAN, MUALLA, Aydin, Hulya Ayik   +5 more
core   +1 more source

EP08.02-041 NVL-520, a Highly Selective ROS1 Inhibitor, in Patients with Advanced ROS1-Positive Solid Tumors: The Phase 1/2 ARROS-1 Study

, 2022
Introduction: Oncogenic ROS1 gene fusions are implicated in the pathogenesis of various adult and pediatric cancers, including up to 3% of non-small cell lung cancers (NSCLC), where up to 40% of patients present with central nervous system (CNS ...
Camidge, D. R, Calles, A., Johnson, M., Lin, J. J, Felip, E., Zhu, V. W, Spira, A., Bauman, J., Besse, B., Liu, S., Haggstrom, D., Elamin, Y., Pelish, H. E, Drilon, A., de Miguel, M. J, Lopes, G., van der Wekken, A. J., Riley, G., Ou, S. H.I, Gadgeel, Shirish M   +19 more
core   +1 more source

Novel insight into mechanisms of ROS1 catalytic activation via loss of the extracellular domain

Scientific Reports
The ROS1 receptor tyrosine kinase (RTK) possesses the largest extracellular amino-terminal domain (ECD) among the human RTK family, yet the mechanisms regulating its activation are not fully understood. While chimeric ROS1 fusion proteins, resulting from
Kristen Jones, Clare Keddy, Chelsea Jenkins, Katelyn Nicholson, Ujwal Shinde, Monika A. Davare   +5 more
doaj   +1 more source

A Real‐World Study: Therapeutic Outcomes of ROS1‐Positive Advanced NSCLC

Thoracic Cancer
Background ROS1 gene rearrangement is an important target for NSCLC treatment. There is not yet sufficient real‐world data on ROS1 diagnostic methods, treatment selection, and clinical outcomes in the Chinese population.
Hanqi Yuan, Zihua Zou, Xuezhi Hao, Yan Li, Junling Li, Jianming Ying, Puyuan Xing   +6 more
doaj   +1 more source

Lung adenocarcinoma patients with ROS1-rearranged tumors by sex and smoking intensity

Heliyon
Background: ROS1 rearrangements (ROS1+) define a distinct molecular subset of lung adenocarcinomas. ROS1 + tumors are known to occur more in never-smokers, but the frequency and outcome of ROS1 positivity by sex and smoking intensity are not clearly ...
Yanmei Peng, Vinicius Ernani, Dan Liu, Qian Guo, Markay Hopps, Joseph C. Cappelleri, Ruchi Gupta, Mariza de Andrade, Jun Chen, Eunhee S. Yi, Ping Yang   +10 more
doaj   +1 more source

Supplementary Figure 1 from Analysis of Receptor Tyrosine Kinase ROS1-Positive Tumors in Non–Small Cell Lung Cancer: Identification of a FIG-ROS1 Fusion

, 2012
PDF file, 3170KB, (A) Schematic representation of the genomic region containing fig and ros1. Probes set 1 derived from ros1 (orange) and the deleted region (green). Probe set 2 derived from ros1 (orange) and fig (green).
Yerong Hu (233501), Herbert Haack (233511), Jennifer S. Mack (14988033), Daiqiang Li (14977056), Matthew R. Silver (14988036), Katherine E. Crosby (14988027), Meghan E. Kelly (14988030), Ting-Lei Gu (5649880), Xinmin Zhou (137494), Victoria M. Rimkunas (14988024)   +9 more
core   +1 more source