Results 121 to 130 of about 22,830 (226)

Resistance Mechanisms in ROS1-Positive Lung Cancer: New Insight into a Rare but Clinically Important Entity

For most clinicians, even most oncologists, ROS proto-oncogene 1, receptor tyrosine kinase (ROS1) fusion lung cancer remains a rare entity never encountered in actual practice.
Gerber, DE, von Itzstein, MS
core   +1 more source

Current treatment and novel insights regarding ROS1‐targeted therapy in malignant tumors

Cancer Medicine
Background The proto‐oncogene ROS1 encodes an intrinsic type I membrane protein of the tyrosine kinase/insulin receptor family. ROS1 facilitates the progression of various malignancies via self‐mutations or rearrangements.
Shizhe Li, He Zhang, Ting Chen, Xiaowen Zhang, Guanning Shang   +4 more
doaj   +1 more source

30P Feasibility of anti-ROS1 SP384 for detection of ROS1 protein [PDF]

Journal of Thoracic Oncology, 2018
I. Menzl, B. Richardson, C. Le, D. Smith, A.E. Hanlon Newell, C. Bell, G. Pate, R.S.P. Huang   +7 more
openaire   +1 more source

Functionally distinct ALK and ROS1 fusions detected in infant-type hemispheric gliomas converge on STAT3 and SHP2 activation

Cell Reports
Summary: ALK and ROS1 fusions are key drivers of infant-type hemispheric gliomas (IHG). With diverse gene partners, the impact of ALK and ROS1 oncoprotein heterogeneity on glioma biology remains unknown.
Andreas Postlmayr, Astrid Sanchez Bergman, Jacob Torrejon Diaz, Bernard Ciraulo, Shen Yan, Nina Hofmann, Samanta Carbajal, Rosalie Dobler, Charbel Machaalani, Marc T. Schönholzer, Laura Priego Gonzalez, Andrea J. De Micheli, Ernesto Berenjeno-Correa, Luca Baroncini, Michael A. Grotzer, Uri Tabori, Cynthia Hawkins, Olivier Ayrault, Marc Zuckermann, Martin Baumgartner, Ana S. Guerreiro Stücklin   +20 more
doaj   +1 more source

Aberrant Expression of ROS1 is Uncommon in Ovarian Cancer

, 2019
Background: The receptor tyrosine kinase ROS1 is overexpressed in multiple cancer types and is demonstrated to drive tumorigenesis by fusing with a number of genes including FIG, CD74, and SLC34A2. However, in the context of ovarian cancer, the frequency
Chen, L, Wang, J, Wong, OGW, Wong, TLI, Cheung, ANY   +4 more
core  

Repotrectinib in ROS1 Fusion–Positive Non–Small-Cell Lung Cancer [PDF]

BACKGROUND The early-generation ROS1 tyrosine kinase inhibitors (TKIs) that are approved for the treatment of ROS1 fusion-positive non-small-cell lung cancer (NSCLC) have antitumor activity, but resistance develops in tumors, and intracranial activity is
de Langen, Adrianus, Dooms, Christophe, Cho, Byoung, Mehta, Minal, Beg, Muhammad Shaalan, Hu, Xiufeng, Cheema, Parneet, Graber, Armin, Solomon, Benjamin J., Lee, Ki, Moro-Sibilot, Denis, Krebs, Matthew G., Camidge, D. Ross, Stopatschinskaja, Shanna, Dziadziuszko, Rafal, Lin, Jessica, Lee, Ki Hyeong, Besse, Benjamin, Sims, Gregory, Beg, Muhammad, Nagasaka, Misako, Camidge, D, Lin, Jessica J., Yuan, Yong, de Langen, Adrianus Johannes, Cho, Byoung Chul, Velcheti, Vamsidhar, Wolf, Jürgen, Yao, Wenxiu, Drilon, Alexander, Felip, Enriqueta, Springfeld, Christoph, Goto, Koichi, Trone, Denise, Kao, Steven, Yang, Nong, Krebs, Matthew, Lu, Shun, Solomon, Benjamin, Kim, Sang-We, Popat, Sanjay   +40 more
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Crizotinib in ROS1-Rearranged Non-Small-Cell Lung Cancer

, 2014
Background Chromosomal rearrangements of the gene encoding ROS1 proto-oncogene receptor tyrosine kinase (ROS1) define a distinct molecular subgroup of non-small-cell lung cancers (NSCLCs) that may be susceptible to therapeutic ROS1 kinase inhibition ...
Tan, Weiwei, Zheng, Zongli, Iafrate, A. John, Stephenson, Patricia, Solomon, Benjamin J., Tye, Lesley M., Wilner, Keith D., Shreeve, S. Martin, Salgia, Ravi, Ou, Sai-Hong I., Doebele, Robert C., Riely, Gregory J., Camidge, D. Ross, Christensen, James G., Shapiro, Geoffrey I., Costa, Daniel B., Shaw, Alice T., Varella-Garcia, Marileila, Clark, Jeffrey W., Long Phi Le, Bang, Yung-Jue   +20 more
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ROS1 Gene [PDF]

, 2020
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ROS1 Negative [PDF]

, 2020
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ROS1 Positive [PDF]

, 2020
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