Results 1 to 10 of about 90,490 (196)

Serverification of Molecular Modeling Applications: The Rosetta Online Server That Includes Everyone (ROSIE) [PDF]

PLoS ONE, 2013
The Rosetta molecular modeling software package provides experimentally tested and rapidly evolving tools for the 3D structure prediction and high-resolution design of proteins, nucleic acids, and a growing number of non-natural polymers.
Sergey Lyskov, Fang-Chieh Chou, Daisuke Kuroda   +2 more
exaly   +9 more sources

Four small puzzles that Rosetta doesn't solve. [PDF]

PLoS ONE, 2011
A complete macromolecule modeling package must be able to solve the simplest structure prediction problems. Despite recent successes in high resolution structure modeling and design, the Rosetta software suite fares poorly on small protein and RNA ...
Rhiju Das
doaj   +7 more sources

HighFold-MeD: a Rosetta distillation model to accelerate structure prediction of cyclic peptides with backbone N-methylation and d-amino acids [PDF]

Journal of Cheminformatics
Abstract Cyclic peptides with backbone N-methylated amino acids (BNMeAAs) and D-amino acids (D-AAs) have gained increasing attention for their stability, membrane permeability, and other therapeutic potentials.
Zhigang Cao, Sen Cao, Linghong Wang, Zhiguo Wang, Qingyi Mao, Jingjing Guo, Hongliang Duan   +6 more
doaj   +2 more sources

Chromatin profiling identifies putative dual roles for H3K27me3 in regulating cell type-specific genes and transposable elements in choanoflagellates [PDF]

Nature Communications
Chromatin-based mechanisms contribute to the exquisite regulation of gene expression during animal development. But how those mechanisms evolved remains elusive.
James M. Gahan, Lily W. Helfrich, Laura A. Wetzel, Natarajan V. Bhanu, Zuo-Fei Yuan, Benjamin A. Garcia, Robert J. Klose, Alex de Mendoza, David S. Booth   +8 more
doaj   +2 more sources

Computational design of peptides to target NaV1.7 channel with high potency and selectivity for the treatment of pain

eLife, 2022
The voltage-gated sodium NaV1.7 channel plays a key role as a mediator of action potential propagation in C-fiber nociceptors and is an established molecular target for pain therapy.
Phuong T Nguyen, Hai M Nguyen, Karen M Wagner, Robert G Stewart, Vikrant Singh, Parashar Thapa, Yi-Je Chen, Mark W Lillya, Anh Tuan Ton, Richard Kondo, Andre Ghetti, Michael W Pennington, Bruce Hammock, Theanne N Griffith, Jon T Sack, Heike Wulff, Vladimir Yarov-Yarovoy   +16 more
doaj   +1 more source

Computational Site Saturation Mutagenesis of Canonical and Non-Canonical Amino Acids to Probe Protein-Peptide Interactions

Frontiers in Molecular Biosciences, 2022
Technologies for discovering peptides as potential therapeutics have rapidly advanced in recent years with significant interest from both academic and pharmaceutical labs.
Jeffrey K. Holden, Ryan Pavlovicz, Alberto Gobbi, Yifan Song, Christian N. Cunningham   +4 more
doaj   +1 more source

Detection of Mycobacterium avium subsp. paratuberculosis from cattle and buffaloes in Egypt using traditional culture, serological and molecular based methods [PDF]

Veterinary World, 2014
Background: Johne's disease (JD) caused by Mycobacterium avium subsp. paratuberculosis (MAP) represents a real threat to the agriculture and dairy food industries and believed to be a potential public health problem.
G. S. Abdellrazeq, M. M. El-Naggar, S. A. Khaliel , A. E. Gamal-Eldin   +3 more
doaj   +1 more source

The PyRosetta Toolkit: a graphical user interface for the Rosetta software suite. [PDF]

PLoS ONE, 2013
The Rosetta Molecular Modeling suite is a command-line-only collection of applications that enable high-resolution modeling and design of proteins and other molecules.
Jared Adolf-Bryfogle, Roland L Dunbrack
doaj   +1 more source

Introduction to the Rosetta Special Collection. [PDF]

PLoS ONE, 2015
The Rosetta macromolecular modeling software is a versatile, rapidly developing set of tools that are now being routinely utilized to address state-of-the-art research challenges in academia and industrial research settings.
Sagar D Khare, Timothy A Whitehead
doaj   +1 more source

Quinze anys de traducció automàtica a l’Estat espanyol

Digithum, 2000
Mai cap fabricant no ha fet una màquina de rentar automàtica que escarneixi la fesomia d'una rentadora humana. Els enginyers han adaptat la tecnologia a la feina i han aconseguit andròmines cúbiques amb aparença de moble de cuina, en comptes d'androides ...
Joseba Abaitua
doaj   +1 more source